Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.54 |
| ▸ | STS | P08842 | 1/20 | 0.54 |
| ▸ | SOD1 | P00441 | 1/20 | 0.53 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4530719 | 0.89 | PDE4B (0.72) | PDE4BHDAC8HDAC1STSHSD17B3 | |
| SCHEMBL28750318 | 0.86 | MMP1 (0.61) | STSHSD17B3HTR7L3MBTL1NPC1 | |
| SCHEMBL1356249 | 0.86 | HSD17B3 (0.69) | HPGDHDAC1STSHSD17B3HTR7 | |
| SCHEMBL705208 | 0.86 | MAPT (0.68) | PDE4BHPGDHDAC8HDAC1STS | |
| SCHEMBL1304627 | 0.84 | PDE4B (0.70) | PDE4BHDAC8HDAC1STSHSD17B3 | |
| SCHEMBL3915570 | 0.83 | PDE4B (0.57) | PDE4BHPGDHDAC8HDAC1STS | |
| SCHEMBL9522917 | 0.83 | HDAC8 (0.69) | PDE4BHDAC8HDAC1STSHSD17B3 | |
| SCHEMBL9520347 | 0.83 | HDAC8 (0.69) | PDE4BHDAC8HDAC1STSHSD17B3 | |
| SCHEMBL12016810 | 0.83 | HDAC8 (0.69) | PDE4BHDAC8HDAC1STSHSD17B3 | |
| SCHEMBL10865339 | 0.83 | HDAC8 (0.69) | PDE4BHDAC8HDAC1STSHSD17B3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035377-A1 | INDOLE DERIVATIVES AND THEIR USE AS THYROID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007134864-A1 | INDOLE DERIVATIVES AND THEIR USE AS THYROID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2007-11-29 | — | — | WO | disclosed |