Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | GSK3A | P49840 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4099571 | 0.94 | NPC1 (0.40) | KCNA5NPC1GSK3AGSK3BSIGMAR1 | |
| SCHEMBL3925802 | 0.92 | KCNA5 (0.50) | KCNA5GSK3AGSK3BSIGMAR1MEN1 | |
| SCHEMBL3917852 | 0.88 | KCNA5 (0.57) | KCNA5GSK3AGSK3BSIGMAR1MEN1 | |
| SCHEMBL3920282 | 0.86 | KCNA5 (0.43) | KCNA5GSK3AGSK3BSIGMAR1DAO | |
| SCHEMBL3916710 | 0.85 | KCNA5 (0.43) | KCNA5GSK3AGSK3BSIGMAR1DAO | |
| SCHEMBL3925563 | 0.85 | KCNA5 (0.44) | KCNA5GSK3AGSK3BSIGMAR1DAO | |
| SCHEMBL3926580 | 0.84 | KCNA5 (0.43) | KCNA5GSK3AGSK3BSIGMAR1MEN1 | |
| SCHEMBL3916295 | 0.84 | KCNA5 (0.46) | KCNA5GSK3AGSK3BSIGMAR1MEN1 | |
| SCHEMBL3925872 | 0.84 | KCNA5 (0.43) | KCNA5GSK3AGSK3BSIGMAR1DAO | |
| SCHEMBL3915932 | 0.83 | KCNA5 (0.60) | KCNA5GSK3AGSK3BSIGMAR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035392-A1 | IMIDAZOLE KV1. 5 POTASSIUM CHANNEL INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007149874-A1 | IMIDAZOLIDINONE KV1.5 POTASSIUM CHANNEL INHIBITORS | WYETH (US) | 2007-12-27 | — | — | WO | disclosed |