Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 6/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.38 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.38 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.38 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3914435 | 0.94 | KCNA5 (0.42) | KCNA5KCNH2DRD2DRD4DRD3 | |
| SCHEMBL3925802 | 0.91 | KCNA5 (0.50) | KCNA5KCNH2GSK3AGSK3BSIGMAR1 | |
| SCHEMBL3916070 | 0.89 | KCNA5 (0.44) | KCNA5KCNH2TSHR | |
| SCHEMBL3917852 | 0.87 | KCNA5 (0.57) | KCNA5KCNH2GSK3AGSK3BSIGMAR1 | |
| SCHEMBL3916710 | 0.84 | KCNA5 (0.43) | KCNA5KCNH2DRD2GSK3AGSK3B | |
| SCHEMBL3925563 | 0.84 | KCNA5 (0.44) | KCNA5KCNH2GSK3AGSK3BSIGMAR1 | |
| SCHEMBL3915740 | 0.84 | KCNA5 (0.44) | KCNA5KCNH2GSK3AGSK3BSIGMAR1 | |
| SCHEMBL3925872 | 0.83 | KCNA5 (0.43) | KCNA5KCNH2GSK3AGSK3BSIGMAR1 | |
| SCHEMBL3920282 | 0.83 | KCNA5 (0.43) | KCNA5KCNH2GSK3AGSK3BSIGMAR1 | |
| SCHEMBL3926580 | 0.83 | KCNA5 (0.43) | KCNA5KCNH2GSK3AGSK3BSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035392-A1 | IMIDAZOLE KV1. 5 POTASSIUM CHANNEL INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2009-03-18 | — | — | EP | claimed |
| WO-2007149874-A1 | IMIDAZOLIDINONE KV1.5 POTASSIUM CHANNEL INHIBITORS | WYETH (US) | 2007-12-27 | — | — | WO | claimed |