Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
| ▸ | MMP13 | P45452 | 3/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 2/20 | 0.36 |
| ▸ | MMP12 | P39900 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CDK16 | Q00536 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3918287 | 1.00 | GSK3B (0.39) | GSK3BMMP13MMP1MMP9KCNA5 | |
| SCHEMBL3915644 | 1.00 | GSK3B (0.39) | GSK3BMMP13MMP1MMP9KCNA5 | |
| SCHEMBL3915836 | 0.95 | KCNA5 (0.41) | GSK3BMMP13MMP1MMP9KCNA5 | |
| SCHEMBL3925882 | 0.88 | CYP3A4 (0.42) | MMP13MMP1MMP9KCNA5ALDH1A1 | |
| SCHEMBL3919270 | 0.86 | CYP3A4 (0.45) | MMP13MMP1MMP9MMP8MMP12 | |
| SCHEMBL3916353 | 0.85 | MMP13 (0.39) | GSK3BMMP13MMP1MMP9KCNA5 | |
| SCHEMBL3915076 | 0.84 | KCNA5 (0.42) | MMP13MMP1MMP9KCNA5 | |
| SCHEMBL3925144 | 0.82 | KCNA5 (0.45) | MMP13MMP1MMP9KCNA5MMP8 | |
| SCHEMBL3925782 | 0.82 | KCNA5 (0.43) | MMP13MMP1MMP9KCNA5MMP8 | |
| SCHEMBL3915793 | 0.81 | KCNA5 (0.46) | GSK3BMMP13MMP1MMP9KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035392-A1 | IMIDAZOLE KV1. 5 POTASSIUM CHANNEL INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007149874-A1 | IMIDAZOLIDINONE KV1.5 POTASSIUM CHANNEL INHIBITORS | WYETH (US) | 2007-12-27 | — | — | WO | disclosed |