Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ACE | P12821 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25175295 | 0.85 | ACE (0.47) | PREPCTSKCHRM2CHRM1CHRM3 | |
| SCHEMBL10137609 | 0.85 | PREP (0.38) | PREPCTSKCHRM2CHRM1CHRM3 | |
| SCHEMBL31375026 | 0.85 | PREP (0.38) | PREPCTSKCHRM2CHRM1CHRM3 | |
| SCHEMBL629586 | 0.85 | ACE (0.47) | PREPCTSKCHRM2CHRM1CHRM3 | |
| SCHEMBL629585 | 0.85 | ACE (0.47) | PREPCTSKCHRM2CHRM1CHRM3 | |
| SCHEMBL1022805 | 0.84 | PIN1 (0.42) | PREPCTSKCHRM2CHRM1CHRM3 | |
| SCHEMBL2559556 | 0.83 | PTPN1 (0.39) | PREPCTSKCHRM2CHRM1CHRM3 | |
| SCHEMBL3546343 | 0.83 | PTPN1 (0.39) | PREPCTSKCHRM2CHRM1CHRM3 | |
| SCHEMBL3546340 | 0.83 | PTPN1 (0.39) | PREPCTSKCHRM2CHRM1CHRM3 | |
| SCHEMBL6940371 | 0.81 | PTPN1 (0.40) | PREPCTSKCHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029571-A1 | SUBSTITUTED 3 -AMINO-4 -HYDROXY PYRROLIDINES COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007128460-A1 | SUBSTITUTED 3 -AMINO-4 -HYDROXY PYRROLIDINES COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-11-15 | — | — | WO | disclosed |