Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 7/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 4/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.39 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | RXRG | P48443 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2896742 | 0.91 | PSEN1 (0.42) | PTPN1PTPN6PTPN2PSEN1PSEN2 | |
| SCHEMBL27702994 | 0.79 | PSEN1 (0.58) | PTPN1PTPN6PTPN2PSEN1PSEN2 | |
| SCHEMBL27684238 | 0.79 | PSEN1 (0.58) | PTPN1PTPN6PTPN2PSEN1PSEN2 | |
| SCHEMBL27684239 | 0.79 | PSEN1 (0.58) | PTPN1PTPN6PTPN2PSEN1PSEN2 | |
| SCHEMBL27793376 | 0.78 | PTPN1 (0.46) | PTPN1PTPN6PTPN2PSEN1PSEN2 | |
| SCHEMBL27703014 | 0.78 | PTPN1 (0.47) | PTPN1PTPN6PTPN2PSEN1PSEN2 | |
| SCHEMBL2904877 | 0.78 | CSNK2B (0.36) | PTPN1PTPN6PTPN2PSEN1PSEN2 | |
| SCHEMBL491320 | 0.77 | PSEN1 (0.67) | PTPN1PTPN6PTPN2PSEN1PSEN2 | |
| SCHEMBL27829116 | 0.74 | PTPN1 (0.34) | PTPN1PTPN6PTPN2PSEN1PSEN2 | |
| SCHEMBL27684198 | 0.73 | ALDH1A1 (0.49) | PTPN1PTPN6PTPN2PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021314-A1 | SUBSTITUTED BIPHENYL CARBOXYLIC ACIDS AND DERIVATIVES THEREOF | Ortho-McNeil Pharmaceutical, Inc. (US) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007124394-A1 | SUBSTITUTED BIPHENYL CARBOXYLIC ACIDS AND DERIVATIVES THEREOF | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2007-11-01 | — | — | WO | disclosed |