Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.38 |
| ▸ | RAD1 | O60671 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.38 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3918002 | 1.00 | ALDH1A1 (0.45) | ALDH1A1LMNATHRBCYP11B1CYP11B2 | |
| SCHEMBL3917279 | 0.92 | PTPN1 (0.46) | LMNAPTPN1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL4443447 | 0.92 | PTPN1 (0.46) | LMNAPTPN1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL3920265 | 0.86 | PTPN1 (0.39) | ALDH1A1LMNATHRBCYP11B1CYP11B2 | |
| SCHEMBL3920267 | 0.86 | PTPN1 (0.39) | ALDH1A1LMNATHRBCYP11B1CYP11B2 | |
| SCHEMBL3918290 | 0.84 | PTPN1 (0.43) | ALDH1A1LMNAPTPN1SMN1; SMN2KDM4E | |
| SCHEMBL3918294 | 0.84 | PTPN1 (0.43) | ALDH1A1LMNAPTPN1SMN1; SMN2KDM4E | |
| SCHEMBL3919349 | 0.83 | KDM4E (0.53) | ALDH1A1LMNAPTPN1SMN1; SMN2KDM4E | |
| SCHEMBL3919344 | 0.83 | KDM4E (0.53) | ALDH1A1LMNAPTPN1SMN1; SMN2KDM4E | |
| SCHEMBL3916346 | 0.83 | PTPN1 (0.45) | ALDH1A1PTPN1POLBKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8084448-B2 | Organic compounds | NOVARTIS AG (CH) | 2011-12-27 | — | — | US | disclosed |
| US-20090181928-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2009-07-16 | — | — | US | disclosed |
| EP-2038267-A2 | THIADIAZOLIDINONE INHIBITORS OF PTPASE | Novartis AG (CH) | 2009-03-25 | — | — | EP | disclosed |
| WO-2007115058-A2 | THIADIAZOLIDINONE INHIBITORS OF PTPASE | NOVARTIS AG (CH) | 2007-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181928-A1 | ORGANIC COMPOUNDS | PTPRS, PTPRO, PTPRC | ALDH1A1 2621/4885LMNA 4825/4885THRB 1246/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.