SCHEMBL3919932

SCHEMBL3919932

CN(C)C=Nc1nc2c(ncn2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2OCCC#N)c(=O)[nH]1

nearest known ligand 0.47

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 2/20 0.47
▸ PAX8 Q06710 1/20 0.41
▸ ADORA2A P29274 5/20 0.40
▸ ADORA3 P0DMS8 2/20 0.40
▸ ADORA1 P30542 2/20 0.40
▸ HINT1 P49773 1/20 0.40
▸ ADORA2B P29275 3/20 0.39
▸ IMPDH2 P12268 2/20 0.39
▸ IMPDH1 P20839 1/20 0.39
▸ TAS1R3 Q7RTX0 1/20 0.38
▸ TAS1R1 Q7RTX1 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13715736 1.00 HPGD (0.47) HPGDPAX8ADORA2AADORA3ADORA1
SCHEMBL13744363 1.00 HPGD (0.47) HPGDPAX8ADORA2AADORA3ADORA1
SCHEMBL7708728 0.88 HPGD (0.52) HPGDPAX8ADORA2AADORA3ADORA1
SCHEMBL7708715 0.88 HPGD (0.52) HPGDPAX8ADORA2AADORA3ADORA1
SCHEMBL31040187 0.86 HPGD (0.46) HPGDPAX8ADORA3ADORA1HINT1
SCHEMBL7259250 0.85 HPGD (0.64) HPGDPAX8ADORA2AADORA3ADORA1
SCHEMBL7259261 0.85 HPGD (0.64) HPGDPAX8ADORA2AADORA3ADORA1
SCHEMBL19128427 0.85 HPGD (0.64) HPGDPAX8ADORA2AADORA3ADORA1
SCHEMBL22571072 0.85 HPGD (0.64) HPGDPAX8ADORA2AADORA3ADORA1
SCHEMBL19035723 0.85 HPGD (0.64) HPGDPAX8ADORA2AADORA3ADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7569685-B2 Artificial RNAóS modified at the 2ó-hydroxyl group JAPAN SCIENCCE AND TECHNOLOGY AGENCY (JP) 2009-08-04 — — US claimed
US-20080021206-A1 Novel Artificial Rnaos Modified At The 2o-Hydroxyl Group JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) 2008-01-24 — — US claimed
EP-1726597-A1 NOVEL ARTIFICIAL RNAóS MODIFIED AT THE 2ó-HYDROXYL GROUP Japan Science and Technology Agency (JP) 2006-11-29 — — EP claimed
US-7569685-B2 Artificial RNAóS modified at the 2ó-hydroxyl group JAPAN SCIENCCE AND TECHNOLOGY AGENCY (JP) 2009-08-04 — — US disclosed
US-20080021206-A1 Novel Artificial Rnaos Modified At The 2o-Hydroxyl Group JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) 2008-01-24 — — US disclosed
EP-1726597-A1 NOVEL ARTIFICIAL RNAóS MODIFIED AT THE 2ó-HYDROXYL GROUP Japan Science and Technology Agency (JP) 2006-11-29 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080021206-A1 Novel Artificial Rnaos Modified At The 2o-Hydroxyl Group FBL, NSUN2, METTL16 HPGD 2770/4885PAX8 2575/4885ADORA2A 762/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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