Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.66 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.63 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | STAT3 | P40763 | 1/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.57 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.57 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.57 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.57 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.57 |
| ▸ | BRAF | P15056 | 10/20 | 0.57 |
| ▸ | RAF1 | P04049 | 8/20 | 0.57 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12323377 | 0.91 | MAPT (0.65) | MAPTCYP1A2CYP2C19KCNQ3KCNQ2 | |
| SCHEMBL1140599 | 0.90 | MAPT (0.63) | MAPTCYP1A2CYP2C19KCNQ3KCNQ2 | |
| SCHEMBL1140524 | 0.90 | MAPT (0.63) | MAPTCYP1A2CYP2C19KCNQ3KCNQ2 | |
| SCHEMBL1140654 | 0.89 | MAPT (0.62) | MAPTCYP1A2CYP2C19KCNQ3KCNQ2 | |
| SCHEMBL12323474 | 0.88 | MAPT (0.61) | MAPTCYP1A2CYP2C19KCNQ3KCNQ2 | |
| SCHEMBL1140865 | 0.87 | MAPT (0.59) | MAPTCYP1A2CYP2C19KCNQ3KCNQ2 | |
| SCHEMBL1140636 | 0.87 | MAPT (0.59) | MAPTCYP1A2CYP2C19KCNQ3KCNQ2 | |
| SCHEMBL1140500 | 0.86 | MAPT (0.58) | MAPTCYP1A2CYP2C19KCNQ3KCNQ2 | |
| SCHEMBL2346560 | 0.86 | RARA (0.66) | MAPTSMN1; SMN2LMNAMAPK14BRAF | |
| SCHEMBL1140474 | 0.83 | KCNQ3 (0.59) | MAPTCYP1A2CYP2C19KCNQ3KCNQ2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038253-A1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | Arrow Therapeutics Limited (GB) | 2009-03-25 | — | — | EP | disclosed |
| WO-2007138242-A1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | ARROW THERAPEUTICS LIMITED (GB) | 2007-12-06 | — | — | WO | disclosed |