Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.48 |
| ▸ | DDR1 | Q08345 | 6/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31536436 | 0.87 | NR1H2 (0.59) | NR1H2DDR1KITBRAF | |
| SCHEMBL3311056 | 0.85 | NR1H2 (0.52) | NR1H2DDR1KITATMHTT | |
| SCHEMBL2707620 | 0.85 | NR1H2 (0.66) | ALDH1A1KDM4ENR1H2DDR1KIT | |
| SCHEMBL2777362 | 0.84 | DDR1 (0.51) | NPSR1ALDH1A1KDM4ENR1H2DDR1 | |
| SCHEMBL30899974 | 0.83 | NPSR1 (0.59) | NPSR1ALDH1A1KDM4EKITBRAF | |
| SCHEMBL3919971 | 0.83 | NR1H2 (0.70) | NPSR1ALDH1A1KDM4ENR1H2DDR1 | |
| SCHEMBL16380735 | 0.83 | NR1H2 (0.49) | NPSR1ALDH1A1KDM4ENR1H2DDR1 | |
| SCHEMBL16380700 | 0.83 | DDR1 (0.50) | NPSR1ALDH1A1KDM4ENR1H2DDR1 | |
| SCHEMBL2707798 | 0.82 | DDR1 (0.56) | NPSR1ALDH1A1KDM4ENR1H2DDR1 | |
| SCHEMBL3992921 | 0.82 | IP6K1 (0.52) | NPSR1ALDH1A1KDM4EDDR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038253-A1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | Arrow Therapeutics Limited (GB) | 2009-03-25 | — | — | EP | disclosed |
| WO-2007138242-A1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | ARROW THERAPEUTICS LIMITED (GB) | 2007-12-06 | — | — | WO | disclosed |