Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22553629 | 0.82 | DPP4 (0.37) | LMNAADORA2AADORA1HSP90AA1HSP90AB1 | |
| SCHEMBL13304569 | 0.82 | TLR8 (0.48) | TLR8KDM4EALDH1A1LMNAHSP90AB1 | |
| SCHEMBL1357635 | 0.75 | DPP4 (0.33) | ADORA2AADORA1DPP4 | |
| SCHEMBL9178364 | 0.75 | KDM4E (0.40) | TLR8KDM4ENPSR1ALDH1A1LMNA | |
| SCHEMBL4289488 | 0.75 | TDP1 (0.31) | — | |
| SCHEMBL559332 | 0.75 | KDM4E (0.40) | TLR8KDM4ENPSR1ALDH1A1LMNA | |
| SCHEMBL20421684 | 0.75 | TLR8 (0.44) | TLR8KDM4ENPSR1ALDH1A1LMNA | |
| SCHEMBL10043017 | 0.75 | ALDH1A1 (0.35) | ALDH1A1 | |
| SCHEMBL3691752 | 0.75 | TLR8 (0.44) | TLR8KDM4EALDH1A1LMNACYP1A2 | |
| SCHEMBL19313320 | 0.75 | TLR8 (0.44) | TLR8KDM4EALDH1A1LMNAHSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 107 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239788-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2024-07-18 | — | — | US | disclosed |
| US-20240239788-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2024-07-18 | — | — | US | disclosed |
| US-20240239788-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2024-07-18 | — | — | US | disclosed |
| EP-4322954-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | Merck Sharp & Dohme LLC (US) | 2024-02-21 | — | — | EP | disclosed |
| US-11773067-B2 | (Trifluoromethyl)pyrimidine-2-amine compounds | ELI LILLY AND COMPANY (US) | 2023-10-03 | — | — | US | disclosed |
| US-11773067-B2 | (Trifluoromethyl)pyrimidine-2-amine compounds | ELI LILLY AND COMPANY (US) | 2023-10-03 | — | — | US | disclosed |
| WO-2022221739-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | MERCK SHARP & DOHME CORP. (US) | 2022-10-20 | — | — | WO | disclosed |
| EP-3527572-B1 | PYRAZOLOPYRIMIDINE COMPOUND AS PI3K INHIBITOR AND USE THEREOF | SHENZHEN BO LI JIAN MEDICINE CO LTD (CN) | 2021-12-22 | — | — | EP | disclosed |
| EP-3527572-B1 | PYRAZOLOPYRIMIDINE COMPOUND AS PI3K INHIBITOR AND USE THEREOF | SHENZHEN BO LI JIAN MEDICINE CO LTD (CN) | 2021-12-22 | — | — | EP | disclosed |
| EP-3160960-B1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES INC (US) | 2021-10-13 | — | — | EP | disclosed |
| EP-2222648-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ASTHMA, COPD, ALLERGIC RHINITIS, ALLERGIC CONJUNCTIVITIS, ATOPIC DERMATITIS, CANCER, HEPATITIS B, HEPATITIS C, HIV, HPV, BACTERIAL INFECTIONS AND DERMATOSIS | AstraZeneca AB (SE) | 2010-09-01 | — | — | EP | disclosed |
| US-20100087456-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF PI3K-ALPHA and mTOR | EXELIXIS, INC. (US) | 2010-04-08 | — | — | US | disclosed |
| US-20100087456-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF PI3K-ALPHA and mTOR | EXELIXIS, INC. (US) | 2010-04-08 | — | — | US | disclosed |
| US-20100087456-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF PI3K-ALPHA and mTOR | EXELIXIS, INC. (US) | 2010-04-08 | — | — | US | disclosed |
| WO-2010039740-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF PI3Kα AND MTOR | EXELIXIS, INC. (US) | 2010-04-08 | — | — | WO | disclosed |
| WO-2010039740-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF PI3Kα AND MTOR | EXELIXIS, INC. (US) | 2010-04-08 | — | — | WO | disclosed |
| WO-2010012740-A1 | 5-ALKYNYL-PYRIMIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-02-04 | — | — | WO | disclosed |
| WO-2010012740-A1 | 5-ALKYNYL-PYRIMIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-02-04 | — | — | WO | disclosed |
| US-20090209524-A1 | Novel Compounds | ASTRAZENECA AB (SE) | 2009-08-20 | — | — | US | disclosed |
| WO-2009067081-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ASTHMA, COPD, ALLERGIC RHINITIS, ALLERGIC CONJUNCTIVITIS, ATOPIC DERMATITIS, CANCER, HEPATITIS B, HEPATITIS C, HIV, HPV, BACTERIAL INFECTIONS AND DERMATOSIS | ASTRAZENECA AB (SE) | 2009-05-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11773067-B2 | (Trifluoromethyl)pyrimidine-2-amine compounds | P2RX1, P2RX2, P2RY1 | TLR8 2007/4885KDM4E 1718/4885NPSR1 51/4885 |
| US-20100087456-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF PI3K-ALPHA and mTOR | PIK3CD, PIK3CA, MTOR | TLR8 3987/4885KDM4E 1759/4885NPSR1 4136/4885 |
| US-20090209524-A1 | Novel Compounds | ABCG2, CYP4B1, CYP3A4 | TLR8 4435/4885KDM4E 2004/4885NPSR1 78/4885 |
| US-20240239788-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | KRAS, NRAS, HRAS | TLR8 4495/4885KDM4E 3110/4885NPSR1 4838/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.