Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.53 |
| ▸ | CHRM5 known ✓ | P08912 | 1/20 | 0.53 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.53 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.53 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.59 |
| ▸ | ESR1 | P03372 | 2/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.53 |
| ▸ | TACR2 | P21452 | 2/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SHBG | P04278 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8656531 | 1.00 | HTR2A (0.59) | HTR2AESR1ADRA2AADORA3TACR2 | |
| SCHEMBL5304765 | 0.98 | HTR2A (0.61) | HTR2AESR1ADRA2AADORA3TACR2 | |
| SCHEMBL5815570 | 0.98 | HTR2A (0.61) | HTR2AESR1ADRA2AADORA3TACR2 | |
| SCHEMBL5303025 | 0.98 | HTR2A (0.61) | HTR2AESR1ADRA2AADORA3TACR2 | |
| SCHEMBL5294380 | 0.98 | HTR2A (0.61) | HTR2AESR1ADRA2AADORA3TACR2 | |
| SCHEMBL5299368 | 0.98 | HTR2A (0.61) | HTR2AESR1ADRA2AADORA3TACR2 | |
| SCHEMBL10645352 | 0.98 | HTR2A (0.61) | HTR2AESR1ADRA2AADORA3TACR2 | |
| SCHEMBL5296180 | 0.98 | HTR2A (0.61) | HTR2AESR1ADRA2AADORA3TACR2 | |
| SCHEMBL5305758 | 0.98 | HTR2A (0.61) | HTR2AESR1ADRA2AADORA3TACR2 | |
| SCHEMBL5299310 | 0.98 | HTR2A (0.61) | HTR2AESR1ADRA2AADORA3TACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7488786-B2 | emulsion polymerization process for producing a polymer by controlled polymerization which comprises polymerizing at least one monomer in the presence of a free radical control agent | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2009-02-10 | — | — | US | disclosed |
| US-7462674-B2 | Oxathiazaphospholidine free radical control agent | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2008-12-09 | — | — | US | disclosed |
| US-20080097057-A1 | Oxathiazaphospholidine free radical control agent | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2008-04-24 | — | — | US | disclosed |
| US-7345186-B2 | Oxathiazaphospholidine free radical control agent | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2008-03-18 | — | — | US | disclosed |
| US-20080033197-A1 | Oxathiazaphospholidine free radical control agent | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2008-02-07 | — | — | US | disclosed |
| EP-1322674-B1 | CONTROL AGENTS FOR LIVING-TYPE FREE RADICAL POLYMERIZATION, METHODS OF POLYMERIZING, EMULSIONS AND POLYMERS WITH SAME | SYMYX TECHNOLOGIES INC (US) | 2006-11-22 | — | — | EP | disclosed |
| US-20060160774-A1 | Oxathiazaphospholidine free radical control agent | THE GOODYEAR TIRE & RUBBER COMPANY | 2006-07-20 | — | — | US | disclosed |
| US-20040073042-A1 | Control agents for living-type free radical polymerization and methods of polymerizing | SYMYX TECHNOLOGIES, INC. | 2004-04-15 | — | — | US | disclosed |
| US-6667376-B2 | Using component having hydroxyamine bonded to thiocarbonyl-sulfide functionality; narrower molecular weight distribu-tion; continuous decrease in polydispersity as monomer conversion increases | SYMYX TECHNOLOGIES, INC. | 2003-12-23 | — | — | US | disclosed |
| US-20030204034-A1 | CONTROL AGENTS FOR LIVING-TYPE FREE RADICAL POLYMERIZATION AND METHODS OF POLYMERIZING | SYMYX TECHNOLOGIES, INC. | 2003-10-30 | — | — | US | disclosed |
| US-6559255-B2 | Using nitrone compound as controller | SYMYX TECHNOLOGIES INC. | 2003-05-06 | — | — | US | disclosed |
| US-6518364-B2 | Subjecting mixture of monomer(s), water, surfactant, free radical source and a control agent to polymerization | SYMYX TECHNOLOGIES, INC. | 2003-02-11 | — | — | US | disclosed |
| US-6472486-B2 | NITROXIDE CONTROL AGENTS HAVING AN ALPHA CARBON ATOM BEARING A DESTABILIZING SUBSTITUENT SUCH AS HYDROGEN | SYMYX TECHNOLOGIES, INC. | 2002-10-29 | — | — | US | disclosed |
| US-20020065380-A1 | Emulsion living-type free radical polymerization, methods and products of same | FREESLATE, INC. | 2002-05-30 | — | — | US | disclosed |
| US-20020061988-A1 | CONTROLLED STABLE FREE RADICAL EMULSION POLYMERIZATION PROCESSES | FREESLATE, INC. | 2002-05-23 | — | — | US | disclosed |
| WO-2002026836-A2 | CONTROL AGENTS FOR LIVING-TYPE FREE RADICAL POLYMERIZATION, METHODS OF POLYMERIZING, EMULSIONS AND POLYMERS WITH SAME | SYMYX TECHNOLOGIES, INC. (US) | 2002-04-04 | — | — | WO | disclosed |
| US-20020013430-A1 | Controlled free radical emulsion and water-based polymerizations and seeded methodologies | FREESLATE, INC. | 2002-01-31 | — | — | US | disclosed |
| US-20020010267-A1 | Polymer segment characterized by a high degree of control over molecular weight, particle size, polydispersity; especially produced using a nitroxide control agent that can be a stable free radical or as an adduct with the initiator | SYMYX TECHNOLOGIES, INC., A DELAWARE CORPORATION | 2002-01-24 | — | — | US | disclosed |
| EP-1165625-A1 | CONTROLLED FREE RADICAL EMULSION AND WATER-BASED POLYMERIZATIONS AND SEEDED METHODOLOGIES | Symyx Technologies, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000053640-A1 | CONTROLLED FREE RADICAL EMULSION AND WATER-BASED POLYMERIZATIONS AND SEEDED METHODOLOGIES | SYMYX TECHNOLOGIES, INC. (US) | 2000-09-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060160774-A1 | Oxathiazaphospholidine free radical control agent | AHR, NOX4, ALK | CHRM2 1171/4885CHRM5 1363/4885CHRM1 563/4885 |
| US-20080033197-A1 | Oxathiazaphospholidine free radical control agent | NOX4, AR, AHR | CHRM2 1336/4885CHRM5 1478/4885CHRM1 528/4885 |
| US-20040073042-A1 | Control agents for living-type free radical polymerization and methods of polymerizing | NOX4, CYBB, MB | CHRM2 3662/4885CHRM5 4175/4885CHRM1 2774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.