Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diazoxide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ11 known ✓ | Q14654 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | LTK | P29376 | 1/20 | 0.40 |
| ▸ | GRK5 | P34947 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | PRKX | P51817 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diazoxide SCHEMBL225394 | 1.00 | CHEK1 (0.40) | CHEK1DAPK3MAP4K4RETPIM1 | |
| Diazoxide SCHEMBL41254 | 0.85 | CHEK1 (0.51) | CHEK1DAPK3MAP4K4RETPIM1 | |
| Diazoxide SCHEMBL29384603 | 0.85 | CHEK1 (0.51) | CHEK1DAPK3MAP4K4RETPIM1 | |
| Diazoxide SCHEMBL1725516 | 0.84 | CHEK1 (0.50) | CHEK1DAPK3MAP4K4RETPIM1 | |
| Diazoxide SCHEMBL1725216 | 0.84 | CHEK1 (0.50) | CHEK1DAPK3MAP4K4RETPIM1 | |
| Diazoxide SCHEMBL1726275 | 0.84 | CHEK1 (0.50) | CHEK1DAPK3MAP4K4RETPIM1 | |
| Diazoxide SCHEMBL28482607 | 0.83 | CHEK1 (0.46) | CHEK1DAPK3MAP4K4RETPIM1 | |
| Choline SCHEMBL29384845 | 0.79 | ALDH1A1 (0.35) | ABCC8KCNJ11ALDH1A1CYP1A2LMNA | |
| Choline SCHEMBL30014691 | 0.79 | ALDH1A1 (0.35) | ABCC8KCNJ11ALDH1A1CYP1A2LMNA | |
| Diazoxide SCHEMBL8646656 | 0.74 | CYP1A2 (0.35) | CHEK1DAPK3MAP4K4RETPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968601-A4 | SALTS OF POTASSIUM ATP CHANNEL OPENERS AND USES THEREOF | ESSENTIALIS INC (US) | 2009-02-25 | — | — | EP | disclosed |
| EP-1968601-A2 | SALTS OF POTASSIUM ATP CHANNEL OPENERS AND USES THEREOF | Essentialis, Inc. (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007081521-A2 | SALTS OF POTASSIUM ATP CHANNEL OPENERS AND USES THEREOF | ESSENTIALIS, INC. (US) | 2007-07-19 | — | — | WO | disclosed |