Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6281515 | 0.85 | MAPT (0.47) | MAPTKDM4ELMNANPC1MEN1 | |
| SCHEMBL2477853 | 0.80 | LMNA (0.54) | SMN1; SMN2MAPTKDM4ELMNAHTT | |
| SCHEMBL16396406 | 0.80 | KMT2A (0.58) | SMN1; SMN2MAPTKDM4ELMNANPC1 | |
| SCHEMBL2522956 | 0.79 | NPC1 (0.59) | SMN1; SMN2MAPTKDM4ELMNAHTT | |
| SCHEMBL7386205 | 0.76 | SMN1; SMN2 (0.65) | SMN1; SMN2KDM4ELMNAHTTNPC1 | |
| SCHEMBL392612 | 0.76 | NPC1 (0.62) | SMN1; SMN2KDM4ELMNAHTTNPC1 | |
| SCHEMBL27915406 | 0.76 | DDR1 (0.46) | SMN1; SMN2KDM4EMEN1KMT2AGAA | |
| SCHEMBL5626806 | 0.75 | PDE4D (0.56) | MAPTKDM4ELMNAHTTNPC1 | |
| SCHEMBL3284705 | 0.75 | KDM4E (0.52) | SMN1; SMN2MAPTKDM4ELMNANPC1 | |
| SCHEMBL9907157 | 0.74 | GSK3B (0.56) | KDM4EMEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024353-A2 | PYRAZOLE COMPOUNDS | Pfizer Products Inc. (US) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007105058-A2 | PYRAZOLE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-09-20 | — | — | WO | disclosed |