Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GABRP | O00591 | 1/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.41 |
| ▸ | GABRE | P78334 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.41 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.41 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.41 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2106218 | 0.89 | EPHX1 (0.41) | EPHX1POLBGNAI3GNAO1GNAI1 | |
| Hydrochloric Acid SCHEMBL3413064 | 0.87 | GNAI3 (0.39) | EPHX1POLBGNAI3GNAO1GNAI1 | |
| Hydrochloric Acid SCHEMBL6016942 | 0.87 | GNAI3 (0.39) | EPHX1POLBGNAI3GNAO1GNAI1 | |
| SCHEMBL13503179 | 0.83 | EPHX1 (0.41) | EPHX1POLBGNAI3GNAO1GNAI1 | |
| SCHEMBL21361032 | 0.83 | EPHX1 (0.41) | EPHX1POLBGNAI3GNAO1GNAI1 | |
| SCHEMBL6371199 | 0.82 | EPHX1 (0.47) | EPHX1POLBGABRPGABRDGABRA1 | |
| SCHEMBL384924 | 0.82 | EPHX1 (0.47) | EPHX1POLBGABRPGABRDGABRA1 | |
| SCHEMBL384923 | 0.82 | EPHX1 (0.47) | EPHX1POLBGABRPGABRDGABRA1 | |
| SCHEMBL23365995 | 0.78 | GAA (0.36) | EPHX1GAAL3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL3337440 | 0.77 | HRH4 (0.42) | EPHX1TSHRCPN1CPB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027107-A1 | 2, 4 -DIAMINO PYRIMIDINES AS CELL CYCLE KINASE INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007132010-A1 | 2, 4 -DIAMINO PYRIMIDINES AS CELL CYCLE KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-11-22 | — | — | WO | disclosed |