Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 13/20 | 0.58 |
| ▸ | GSK3B | P49841 | 6/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.55 |
| ▸ | KIT | P10721 | 2/20 | 0.49 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13650217 | 0.90 | AKT2 (0.71) | AKT2GSK3BAURKARPS6KB1KIT | |
| SCHEMBL1003058 | 0.89 | RPS6KB1 (0.61) | AKT2GSK3BAURKARPS6KB1KIT | |
| SCHEMBL1003001 | 0.87 | AKT2 (0.75) | AKT2GSK3BRPS6KB1KITAKT1 | |
| SCHEMBL1002503 | 0.86 | AKT2 (0.54) | AKT2GSK3BAURKARPS6KB1KIT | |
| SCHEMBL3928238 | 0.83 | AKT2 (0.57) | AKT2GSK3BKITAKT1ROCK2 | |
| SCHEMBL1001795 | 0.78 | AKT2 (0.75) | AKT2GSK3BRPS6KB1AKT1ROCK2 | |
| SCHEMBL3928264 | 0.78 | AKT2 (0.56) | AKT2GSK3BAKT1JAK3JAK2 | |
| SCHEMBL1002967 | 0.77 | AKT2 (0.54) | AKT2GSK3BAURKARPS6KB1KIT | |
| SCHEMBL1003418 | 0.77 | AKT2 (0.64) | AKT2GSK3BKITAKT1ROCK2 | |
| SCHEMBL1003072 | 0.76 | AKT2 (0.79) | AKT2GSK3BRPS6KB1KITAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037931-A2 | PHARMACEUTICAL COMBINATIONS OF PK INHIBITORS AND OTHER ACTIVE AGENTS | Astex Therapeutics Limited (GB) | 2009-03-25 | — | — | EP | disclosed |
| WO-2007125310-A2 | PHARMACEUTICAL COMBINATIONS OF PK INHIBITORS AND OTHER ACTIVE AGENTS | ASTEX THERAPEUTICS LIMITED (GB) | 2007-11-08 | — | — | WO | disclosed |