Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 10/20 | 0.56 |
| ▸ | GSK3B | P49841 | 4/20 | 0.56 |
| ▸ | AKT1 | P31749 | 2/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 6/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.42 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1001701 | 0.90 | AKT2 (0.68) | AKT2GSK3BAKT1PRMT5JAK3 | |
| SCHEMBL1001819 | 0.89 | AKT2 (0.50) | AKT2GSK3BPRMT5EGFRTTBK1 | |
| SCHEMBL1001795 | 0.86 | AKT2 (0.75) | AKT2GSK3BAKT1JAK3JAK2 | |
| SCHEMBL1002967 | 0.85 | AKT2 (0.54) | AKT2GSK3BAKT1 | |
| SCHEMBL3922121 | 0.78 | AKT2 (0.58) | AKT2GSK3BAKT1JAK3JAK2 | |
| SCHEMBL12585890 | 0.78 | AKT2 (0.71) | AKT2GSK3BAKT1JAK3 | |
| SCHEMBL2782083 | 0.77 | AKT2 (0.59) | AKT2GSK3BAKT1 | |
| SCHEMBL12585899 | 0.77 | AKT2 (0.52) | AKT2GSK3BAKT1PRMT5 | |
| SCHEMBL19368681 | 0.75 | AKT2 (0.80) | AKT2GSK3BAKT1JAK3 | |
| SCHEMBL13540013 | 0.75 | AKT2 (0.80) | AKT2GSK3BAKT1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037931-A2 | PHARMACEUTICAL COMBINATIONS OF PK INHIBITORS AND OTHER ACTIVE AGENTS | Astex Therapeutics Limited (GB) | 2009-03-25 | — | — | EP | disclosed |
| WO-2007125310-A2 | PHARMACEUTICAL COMBINATIONS OF PK INHIBITORS AND OTHER ACTIVE AGENTS | ASTEX THERAPEUTICS LIMITED (GB) | 2007-11-08 | — | — | WO | disclosed |