Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.51 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.47 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8991726 | 1.00 | P2RX4 (0.55) | P2RX4ALDH1A1SERPINE1EPHX1LMNA | |
| SCHEMBL473782 | 1.00 | P2RX4 (0.55) | P2RX4ALDH1A1SERPINE1EPHX1LMNA | |
| SCHEMBL17473729 | 1.00 | P2RX4 (0.55) | P2RX4ALDH1A1SERPINE1EPHX1LMNA | |
| SCHEMBL12962519 | 1.00 | P2RX4 (0.55) | P2RX4ALDH1A1SERPINE1EPHX1LMNA | |
| SCHEMBL10028312 | 1.00 | P2RX4 (0.55) | P2RX4ALDH1A1SERPINE1EPHX1LMNA | |
| SCHEMBL5689239 | 1.00 | P2RX4 (0.55) | P2RX4ALDH1A1SERPINE1EPHX1LMNA | |
| SCHEMBL16518819 | 1.00 | P2RX4 (0.55) | P2RX4ALDH1A1SERPINE1EPHX1LMNA | |
| SCHEMBL5825056 | 1.00 | P2RX4 (0.55) | P2RX4ALDH1A1SERPINE1EPHX1LMNA | |
| Hydrochloric Acid SCHEMBL8916611 | 0.98 | P2RX4 (0.54) | P2RX4ALDH1A1SERPINE1EPHX1LMNA | |
| SCHEMBL16158123 | 0.87 | P2RX4 (0.55) | P2RX4ALDH1A1SERPINE1EPHX1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797065-A4 | ACYCLIC 1,3-DIAMINES AND USES THEREFOR | SMITHKLINE BEECHAM CORP (US) | 2009-03-04 | — | — | EP | disclosed |
| US-20070259965-A1 | Acyclic 1,3-Diamine And Uses Therefor | SMITHKLINE BEECHAM CORPORATION | 2007-11-08 | — | — | US | disclosed |
| EP-1797065-A2 | ACYCLIC 1,3-DIAMINES AND USES THEREFOR | SMITHKLINE BEECHAM CORPORATION (US) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006029210-A2 | ACYCLIC 1,3-DIAMINES AND USES THEREFOR | SMITHKLINE BEECHAM CORPORATION (US) | 2006-03-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259965-A1 | Acyclic 1,3-Diamine And Uses Therefor | TRPV4, TRPC4, TRPV1 | P2RX4 81/4885ALDH1A1 949/4885SERPINE1 3831/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.