Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.65 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.65 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.65 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.60 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.60 |
| ▸ | MME | P08473 | 1/20 | 0.59 |
| ▸ | CPA1 | P15085 | 1/20 | 0.59 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.59 |
| ▸ | CTSS | P25774 | 4/20 | 0.58 |
| ▸ | CTSK | P43235 | 3/20 | 0.58 |
| ▸ | CTSB | P07858 | 2/20 | 0.58 |
| ▸ | CTSL | P07711 | 1/20 | 0.58 |
| ▸ | MMP13 | P45452 | 1/20 | 0.57 |
| ▸ | PPARA | Q07869 | 5/20 | 0.57 |
| ▸ | PPARG | P37231 | 4/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | PPARD | Q03181 | 2/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.53 |
| ▸ | BCL2 | P10415 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3923937 | 1.00 | ACE (0.65) | ACEITGB3ITGA2BPTPN1SCN9A | |
| SCHEMBL3925152 | 1.00 | ACE (0.65) | ACEITGB3ITGA2BPTPN1SCN9A | |
| SCHEMBL2290444 | 1.00 | ACE (0.65) | ACEITGB3ITGA2BPTPN1SCN9A | |
| SCHEMBL2291767 | 0.94 | ITGB3 (0.71) | ACEITGB3ITGA2BPTPN1SCN9A | |
| SCHEMBL2291775 | 0.94 | ITGB3 (0.71) | ACEITGB3ITGA2BPTPN1SCN9A | |
| SCHEMBL2289496 | 0.94 | PPARA (0.66) | ACEITGB3ITGA2BPTPN1SCN9A | |
| SCHEMBL4739863 | 0.93 | ACE (0.60) | ACEITGB3ITGA2BPTPN1SCN9A | |
| SCHEMBL2296993 | 0.92 | PPARA (0.67) | ACEITGB3ITGA2BPTPN1SCN9A | |
| SCHEMBL2290585 | 0.90 | ITGB3 (0.62) | ACEITGB3ITGA2BPTPN1SCN9A | |
| SCHEMBL2290589 | 0.90 | ITGB3 (0.62) | ACEITGB3ITGA2BPTPN1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009009035-A1 | SOMATOSTATIN ANALOG AND USES THEREOF | IPSEN PHARMA S.A.S. (FR) | 2009-01-15 | — | — | WO | disclosed |
| EP-0662481-B1 | Spiro piperidines and homologs promote release of growth hormone | MERCK & CO INC (US) | 1999-03-24 | — | — | EP | disclosed |
| US-5578593-A | RELEASING GROWTH HORMONES FOR ANIMALS | MERCK & CO., INC. (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0662481-A1 | Spiro piperidines and homologs promote release of growth hormone | MERCK & CO. INC. (US) | 1995-07-12 | — | — | EP | disclosed |
| WO-1994019367-A1 | SPIRO PIPERIDINES AND HOMOLOGS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-09-01 | — | — | WO | disclosed |