Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.37 |
| ▸ | PLK4 | O00444 | 3/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 3/20 | 0.37 |
| ▸ | CDK1 | P06493 | 3/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.37 |
| ▸ | CDK2 | P24941 | 3/20 | 0.37 |
| ▸ | TYK2 | P29597 | 3/20 | 0.37 |
| ▸ | CLK2 | P49760 | 3/20 | 0.37 |
| ▸ | JAK3 | P52333 | 3/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.37 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.37 |
| ▸ | HIPK4 | Q8NE63 | 3/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.37 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.37 |
| ▸ | AURKA | O14965 | 3/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3924187 | 0.93 | HPGD (0.43) | AURKBPLK4DAPK3JAK2CDK1 | |
| SCHEMBL394707 | 0.89 | HPGD (0.43) | AURKBAURKAMAPK1HPGDKDM4E | |
| SCHEMBL3925098 | 0.84 | BRD4 (0.38) | BRD4JAK1ALDH1A1CYP17A1AAK1 | |
| SCHEMBL3920426 | 0.84 | MAPT (0.44) | BRD4AURKBAURKAKDM4EALDH1A1 | |
| SCHEMBL3926561 | 0.83 | EGFR (0.35) | HPGDKDM4EALDH1A1LMNATSHR | |
| SCHEMBL3917990 | 0.80 | ALDH1A1 (0.45) | HPGDALDH1A1LMNATSHRHSD17B10 | |
| SCHEMBL13938254 | 0.79 | CA12 (0.40) | HPGDKDM4EALDH1A1LMNATSHR | |
| SCHEMBL13686400 | 0.77 | TNF (0.38) | MAPK1HPGDKDM4EALDH1A1LMNA | |
| SCHEMBL14198298 | 0.76 | GAA (0.35) | KDM4EALDH1A1LMNATSHRHSD17B10 | |
| SCHEMBL4894923 | 0.74 | CYP1A2 (0.42) | MAPK1ALDH1A1LMNATSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786807-B1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2009-07-29 | — | — | EP | disclosed |
| US-7479489-B2 | Heterocyclic antiviral compounds | ROCHE PALO ALTO LLC (US) | 2009-01-20 | — | — | US | disclosed |
| US-20060040927-A1 | Heterocyclic antiviral compounds | ROCHE PALO ALTO LLC | 2006-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060040927-A1 | Heterocyclic antiviral compounds | HAVCR2, POLR1A, HCCS | BRD4 1905/4885AURKB 2006/4885PLK4 3372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.