Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 12/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 11/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.46 |
| ▸ | OGFRL1 | Q5TC84 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.40 |
| ▸ | CHRNG | P07510 | 1/20 | 0.40 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | CHRND | Q07001 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | ICMT | O60725 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4254876 | 0.98 | OPRL1 (0.44) | OPRM1OPRL1OPRK1OGFRL1SLC6A3 | |
| SCHEMBL526471 | 0.83 | OPRM1 (0.52) | OPRM1OPRL1OPRK1OGFRL1SLC6A3 | |
| Hydrochloric Acid SCHEMBL517257 | 0.82 | OPRM1 (0.51) | OPRM1OPRL1OPRK1OGFRL1SLC6A3 | |
| SCHEMBL2202322 | 0.82 | OPRL1 (0.70) | OPRM1OPRL1OPRK1 | |
| Hydrochloric Acid SCHEMBL517855 | 0.80 | OPRL1 (0.68) | OPRM1OPRL1OPRK1 | |
| SCHEMBL613906 | 0.79 | OPRM1 (0.49) | OPRM1OPRL1OPRK1SLC6A3CHRNA1 | |
| SCHEMBL5164903 | 0.77 | SLC6A4 (0.44) | OPRM1OPRL1OPRK1SLC6A3SLC6A2 | |
| SCHEMBL5167951 | 0.77 | SLC6A4 (0.44) | OPRM1OPRL1OPRK1SLC6A3SLC6A2 | |
| SCHEMBL9248206 | 0.76 | KMT2A (0.41) | OPRM1SLC6A3CHRNA1CHRNGCHRNB1 | |
| Hydrochloric Acid SCHEMBL5361366 | 0.76 | KCNH2 (0.45) | OPRM1OPRL1OPRK1SLC6A3SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041142-B1 | SPIROCYCLIC AZAINDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2013-10-09 | — | — | EP | disclosed |
| EP-2041142-A1 | SPIROCYCLIC AZAINDOLE DERIVATIVES | Grünenthal GmbH (DE) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008009416-A1 | SPIROCYCLIC AZAINDOLE DERIVATIVES | Grünenthal GmbH (DE) | 2008-01-24 | — | — | WO | disclosed |