Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 13/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 7/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4014812 | 0.90 | CNR1 (0.54) | CNR2CNR1TSHR | |
| SCHEMBL4009905 | 0.90 | CNR1 (0.54) | CNR2CNR1TSHR | |
| SCHEMBL4012883 | 0.90 | CNR1 (0.54) | CNR2CNR1TSHR | |
| SCHEMBL4013626 | 0.88 | CNR1 (0.56) | CNR2SCN9ACNR1 | |
| SCHEMBL3924944 | 0.86 | CNR1 (0.45) | CNR2SCN9ACNR1SCN10A | |
| SCHEMBL3818296 | 0.83 | CNR2 (0.48) | CNR2SCN9ACNR1TSHRSCN10A | |
| SCHEMBL3818740 | 0.83 | CNR2 (0.48) | CNR2SCN9ACNR1TSHRSCN10A | |
| SCHEMBL3818299 | 0.83 | CNR2 (0.48) | CNR2SCN9ACNR1TSHRSCN10A | |
| SCHEMBL3914314 | 0.79 | CNR2 (0.44) | CNR2SCN9ACNR1SCN10A | |
| SCHEMBL3919739 | 0.79 | CNR2 (0.44) | CNR2SCN9ACNR1SCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035394-A1 | 2-PYRAZINECARBOXAMIDE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007147746-A1 | 2-PYRAZINECARBOXAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-12-27 | — | — | WO | disclosed |