Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 8/20 | 0.45 |
| ▸ | CNR2 | P34972 | 3/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | CKS1B | P61024 | 1/20 | 0.38 |
| ▸ | SKP1 | P63208 | 1/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4013474 | 0.92 | CNR1 (0.54) | CNR1CNR2SCN10AHPGDS | |
| SCHEMBL4013626 | 0.91 | CNR1 (0.56) | CNR1CNR2SCN9ACKS1BSKP1 | |
| SCHEMBL3919739 | 0.86 | CNR2 (0.44) | CNR1CNR2SCN9ASCN10ACKS1B | |
| SCHEMBL3914314 | 0.86 | CNR2 (0.44) | CNR1CNR2SCN9ASCN10ACKS1B | |
| SCHEMBL3924497 | 0.86 | CNR2 (0.44) | CNR1CNR2SCN9ASCN10A | |
| SCHEMBL3813909 | 0.85 | CNR1 (0.40) | CNR1CNR2SCN9APTGS2CKS1B | |
| SCHEMBL1379050 | 0.82 | CNR1 (0.66) | CNR1CNR2SCN10APTGS2HPGDS | |
| SCHEMBL4013599 | 0.81 | CNR1 (0.57) | CNR1CNR2 | |
| SCHEMBL4018515 | 0.80 | CNR1 (0.54) | CNR1CNR2SCN10AHPGDS | |
| SCHEMBL3914894 | 0.80 | CNR1 (0.42) | CNR1CNR2SCN9ASCN10ACKS1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035394-A1 | 2-PYRAZINECARBOXAMIDE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007147746-A1 | 2-PYRAZINECARBOXAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-12-27 | — | — | WO | disclosed |