Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.47 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27623623 | 0.84 | SLC22A6 (0.69) | SLC22A6MAPK1PBRM1GPR84NR4A2 | |
| SCHEMBL27790479 | 0.84 | MAPK1 (0.52) | SLC22A6MAPK1PBRM1GPR84NR4A2 | |
| SCHEMBL28768822 | 0.81 | SLC22A6 (0.70) | SLC22A6MAPK1PBRM1GPR84NR4A2 | |
| SCHEMBL2704556 | 0.81 | SLC22A6 (0.74) | SLC22A6MAPK1PBRM1GPR84NR4A2 | |
| SCHEMBL27729377 | 0.81 | SLC22A6 (0.74) | SLC22A6MAPK1PBRM1GPR84NR4A2 | |
| SCHEMBL31181908 | 0.80 | SLC22A6 (0.59) | SLC22A6MAPK1PBRM1GPR84NR4A2 | |
| SCHEMBL23295617 | 0.80 | SLC22A6 (0.72) | SLC22A6MAPK1PBRM1GPR84NR4A2 | |
| SCHEMBL1831734 | 0.80 | SLC22A6 (0.72) | SLC22A6PBRM1GPR84NR4A2CREBBP | |
| SCHEMBL2936460 | 0.79 | TRPA1 (0.46) | SLC22A6MAPK1ALDH1A1LMNAAHR | |
| Indole Acetate SCHEMBL15553 | 0.78 | SLC22A6 (1.00) | SLC22A6PBRM1GPR84NR4A2CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009009411-A1 | SUBSTITUTED HETEROCYCLIC ETHERS AND THEIR USE IN CNS DISORDERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-01-15 | — | — | WO | claimed |
| EP-1945305-A2 | INDOLE AND AZAINDOLE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES | BRANE DISCOVERY S.R.L. (IT) | 2008-07-23 | — | — | EP | claimed |
| WO-2007048847-A2 | INDOLE AND AZAINDOLE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES | NIKEM RESEARCH S.R.L. (IT) | 2007-05-03 | — | — | WO | claimed |
| EP-1750687-A2 | INDOLE AND AZAINDOLE DERIVATIVES WITH ANTITUMOR ACTION | NIKEM RESEARCH S.R.L. (IT) | 2007-02-14 | — | — | EP | claimed |
| EP-1648881-A1 | SUBSTITUTED INDOLE LIGANDS FOR THE ORL-1 RECEPTOR | GlaxoSmithKline S.p.A. (IT) | 2006-04-26 | — | — | EP | claimed |
| WO-2005105213-A2 | INDOLE AND AZAINDOLE DERIVATIVES WITH ANTITUMOR ACTION | NIKEM RESEARCH S.R.L. (IT) | 2005-11-10 | — | — | WO | claimed |
| WO-2005005411-A1 | SUBSTITUTED INDOLE LIGANDS FOR THE ORL-1 RECEPTOR | GLAXOSMITHKLINE S.P.A. (IT) | 2005-01-20 | — | — | WO | claimed |
| CN-114057759-B | Fused tetracyclic derivative, preparation method thereof and application thereof in medicines | 江苏恒瑞医药股份有限公司 | 2023-05-16 | — | — | CN | disclosed |
| CN-113121527-A | Tricyclic compound and use thereof | 上海辉启生物医药科技有限公司 | 2021-07-16 | — | — | CN | disclosed |
| CN-106459055-B | Difunctional cytotoxic drug agent | PFIZER INC. (US) | 2019-11-01 | — | — | CN | disclosed |
| CN-106459055-A | Bifunctional cytotoxic agents | 辉瑞大药厂 | 2017-02-22 | — | — | CN | disclosed |
| CN-105120863-A | Alkylamine peganine derivatives for promoting bone growth | OSTEOQC INC | 2015-12-02 | — | — | CN | disclosed |
| EP-2134714-A1 | TRICYCLIC ISOQUINOLINE DERIVATIVES FOR TREATMENT OF OBESITY | Biovitrum AB (publ) (SE) | 2009-12-23 | — | — | EP | disclosed |
| WO-2007048847-A2 | INDOLE AND AZAINDOLE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES | NIKEM RESEARCH S.R.L. (IT) | 2007-05-03 | — | — | WO | disclosed |
| EP-1750687-A2 | INDOLE AND AZAINDOLE DERIVATIVES WITH ANTITUMOR ACTION | NIKEM RESEARCH S.R.L. (IT) | 2007-02-14 | — | — | EP | disclosed |
| EP-1648881-A1 | SUBSTITUTED INDOLE LIGANDS FOR THE ORL-1 RECEPTOR | GlaxoSmithKline S.p.A. (IT) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005105213-A2 | INDOLE AND AZAINDOLE DERIVATIVES WITH ANTITUMOR ACTION | NIKEM RESEARCH S.R.L. (IT) | 2005-11-10 | — | — | WO | disclosed |
| WO-2005005411-A1 | SUBSTITUTED INDOLE LIGANDS FOR THE ORL-1 RECEPTOR | GLAXOSMITHKLINE S.P.A. (IT) | 2005-01-20 | — | — | WO | disclosed |
| EP-1325008-A1 | PIPERAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-07-09 | — | — | EP | disclosed |
| WO-2002010169-A1 | PIPERAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-02-07 | — | — | WO | disclosed |