Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 7/20 | 0.67 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.56 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NAMPT | P43490 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3926321 | 1.00 | HDAC1 (0.67) | HDAC1HDAC8HDAC4MEF2DHDAC3 | |
| SCHEMBL21710759 | 0.85 | HDAC1 (0.90) | HDAC1HDAC8HDAC4MEF2DHDAC3 | |
| SCHEMBL3916969 | 0.84 | HDAC8 (0.47) | HDAC1HDAC8NPC1RAB9AMEN1 | |
| SCHEMBL1403586 | 0.80 | HDAC1 (1.00) | HDAC1HDAC8HDAC4HDAC3HDAC2 | |
| SCHEMBL1403584 | 0.80 | HDAC1 (1.00) | HDAC1HDAC8HDAC4HDAC3HDAC2 | |
| SCHEMBL3919498 | 0.79 | SMN1; SMN2 (0.48) | MEN1KMT2ANAMPTPOLBALDH1A1 | |
| SCHEMBL9568557 | 0.77 | SMN1; SMN2 (0.58) | KMT2ANAMPTALDH1A1SMN1; SMN2 | |
| SCHEMBL8254056 | 0.76 | HDAC1 (0.77) | HDAC1HDAC8HDAC4MEF2DHDAC3 | |
| SCHEMBL3917001 | 0.75 | ALPL (0.57) | NPC1RAB9ANAMPTPOLBALDH1A1 | |
| SCHEMBL5020623 | 0.75 | HDAC1 (0.72) | HDAC1HDAC8HDAC4HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7495022-B2 | α,β-unsaturated hydroxamic acid derivatives and their use as histone deacetylase inhibitors | SK CHEMICALS CO., LTD. (KR) | 2009-02-24 | — | — | US | disclosed |
| US-20050124679-A1 | Alpha, beta-unsaturated hydroxamic acid derivatives and their use as histone deacetylase inhibitors | SK CHEMICALS CO., LTD. (KR) | 2005-06-09 | — | — | US | disclosed |
| WO-2003087066-A1 | α,β-UNSATURATED HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | SK CHEMICALS, CO., LTD. (KR) | 2003-10-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124679-A1 | Alpha, beta-unsaturated hydroxamic acid derivatives and their use as histone deacetylase inhibitors | HDAC1, HDAC5, HDAC9 | HDAC1 1/4885HDAC8 5/4885HDAC4 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.