Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 13/20 | 0.35 |
| ▸ | JAK1 | P23458 | 12/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.32 |
| ▸ | PARP1 | P09874 | 2/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PRKCB | P05771 | 1/20 | 0.31 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | CLK1 | P49759 | 1/20 | 0.31 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.31 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2576996 | 0.68 | PDPK1 (0.52) | ALDH1A1HSD17B10CSNK2A1PARP1PDPK1 | |
| SCHEMBL20551383 | 0.68 | CCR8 (0.34) | PARP1PDPK1DAO | |
| SCHEMBL3183021 | 0.65 | NPC1 (0.40) | JAK2JAK1ALDH1A1HSD17B10PARP1 | |
| SCHEMBL11920260 | 0.65 | PDPK1 (0.42) | ALDH1A1PARP1PDPK1 | |
| SCHEMBL29156422 | 0.65 | PIM3 (0.35) | MELK | |
| SCHEMBL764250 | 0.63 | ALDH1A1 (0.41) | ALDH1A1HSD17B10 | |
| SCHEMBL2088376 | 0.63 | ALDH1A1 (0.45) | ALDH1A1HSD17B10 | |
| SCHEMBL10883913 | 0.63 | ALDH1A1 (0.45) | ALDH1A1HSD17B10 | |
| SCHEMBL197613 | 0.63 | ALDH1A1 (0.45) | ALDH1A1HSD17B10 | |
| SCHEMBL2435365 | 0.63 | PARP1 (0.42) | ALDH1A1HSD17B10PARP1PDPK1DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035436-A1 | FUSED THIAZOLE DERIVATIVES AS KINASE INHIBITORS | UCB Pharma S.A. (BE) | 2009-03-18 | — | — | EP | disclosed |
| WO-2008001076-A1 | FUSED THIAZOLE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2008-01-03 | — | — | WO | disclosed |