Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 5/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3915648 | 0.91 | KCNA5 (0.53) | KCNA5LMNAHTTMEN1KMT2A | |
| SCHEMBL3925887 | 0.90 | KCNA5 (0.52) | KCNA5POLBLMNAHTTMEN1 | |
| SCHEMBL3918373 | 0.87 | KCNA5 (0.52) | KCNA5LMNAGAAHTTMEN1 | |
| SCHEMBL3917567 | 0.85 | KCNA5 (0.49) | KCNA5POLBLMNASMN1; SMN2HTT | |
| SCHEMBL3915640 | 0.85 | KCNA5 (0.51) | KCNA5LMNAHTTMEN1KMT2A | |
| SCHEMBL3914500 | 0.85 | KCNA5 (0.52) | KCNA5MEN1KMT2AALDH1A1 | |
| SCHEMBL3918641 | 0.85 | KCNA5 (0.45) | KCNA5POLBLMNARECQLSMN1; SMN2 | |
| SCHEMBL3915650 | 0.84 | KCNA5 (0.50) | KCNA5POLBLMNASMN1; SMN2HTT | |
| SCHEMBL3916097 | 0.84 | KCNA5 (0.48) | KCNA5POLBLMNASMN1; SMN2HTT | |
| SCHEMBL3920496 | 0.83 | KCNA5 (0.47) | KCNA5LMNAHTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035392-A1 | IMIDAZOLE KV1. 5 POTASSIUM CHANNEL INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007149874-A1 | IMIDAZOLIDINONE KV1.5 POTASSIUM CHANNEL INHIBITORS | WYETH (US) | 2007-12-27 | — | — | WO | disclosed |