Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 2/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.38 |
| ▸ | CDK2 | P24941 | 5/20 | 0.38 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 5/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.34 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3926962 | 0.94 | NUDT1 (0.41) | NUDT1ACVR1CCNE1CDK2MAP4K1 | |
| SCHEMBL15485367 | 0.94 | NUDT1 (0.41) | NUDT1ACVR1CCNE1CDK2MAP4K1 | |
| SCHEMBL3925554 | 0.93 | NUDT1 (0.40) | NUDT1ACVR1MAP4K1 | |
| SCHEMBL3935547 | 0.93 | NUDT1 (0.40) | NUDT1ACVR1MAP4K1 | |
| SCHEMBL3926845 | 0.93 | NUDT1 (0.41) | NUDT1ACVR1CCNE1CDK2MAP4K1 | |
| SCHEMBL15485274 | 0.92 | NUDT1 (0.39) | NUDT1ACVR1CCNE1CDK2MAP4K1 | |
| SCHEMBL3922255 | 0.91 | NUDT1 (0.41) | NUDT1ACVR1CCNE1CDK2MAP4K1 | |
| SCHEMBL3931611 | 0.90 | NUDT1 (0.40) | NUDT1ACVR1MAP4K1 | |
| SCHEMBL3932770 | 0.90 | NUDT1 (0.40) | NUDT1ACVR1MAP4K1 | |
| SCHEMBL3928621 | 0.90 | NUDT1 (0.42) | NUDT1ACVR1CCNE1CDK2MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051980-B1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2014-02-26 | — | — | EP | disclosed |
| US-7531539-B2 | Pyrrolotriazine kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-05-12 | — | — | US | disclosed |
| US-20080045496-A1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045496-A1 | PYRROLOTRIAZINE KINASE INHIBITORS | JAK2, NTRK2, NTRK3 | NUDT1 4271/4885ACVR1 1835/4885CCNE1 855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.