Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 20/20 | 0.69 |
| ▸ | SOAT1 | P35610 | 6/20 | 0.65 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.55 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3548447 | 0.91 | DGAT1 (0.83) | DGAT1SOAT1DGAT2 | |
| SCHEMBL5249259 | 0.89 | DGAT1 (0.60) | DGAT1SOAT1 | |
| SCHEMBL3471197 | 0.88 | DGAT1 (0.65) | DGAT1SOAT1 | |
| SCHEMBL5254069 | 0.87 | DGAT1 (0.58) | DGAT1SOAT1 | |
| SCHEMBL15638678 | 0.86 | DGAT1 (0.57) | DGAT1SOAT1DGAT2ACAT1 | |
| SCHEMBL4788842 | 0.86 | DGAT1 (0.62) | DGAT1SOAT1 | |
| SCHEMBL4787021 | 0.86 | DGAT1 (0.65) | DGAT1SOAT1 | |
| SCHEMBL5302124 | 0.85 | DGAT1 (0.71) | DGAT1SOAT1 | |
| SCHEMBL5306081 | 0.85 | DGAT1 (0.67) | DGAT1SOAT1 | |
| SCHEMBL3545111 | 0.84 | DGAT1 (0.68) | DGAT1SOAT1DGAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008129319-A1 | SALTS OF OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | claimed |
| EP-2041101-A1 | CRYSTALLINE FORM OF (TRANS-4- [ ( { 5- [ (3, 4 -DI FLUOROPHENYL) AMINO]-1,3, 4-OXADIAZOL-2-YL}CARBONYL) AMINO]PH ENYL } CYCLOHEXYL) ACETIC ACID | AstraZeneca AB (SE) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008129319-A1 | SALTS OF OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |
| WO-2007144571-A1 | CRYSTALLINE FORM OF (TRANS-4- [ ( { 5- [ (3, 4 -DI FLUOROPHENYL) AMINO] -1,3, 4-OXADIAZOL-2-YL}CARBONYL) AMINO] PH ENYL } CYCLOHEXYL) ACETIC ACID | ASTRAZENECA AB (SE) | 2007-12-21 | — | — | WO | disclosed |