Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3940090 | 0.88 | CHRNA7 (0.47) | CHRNA7CHRNB2CHRNA4KCNH2DRD2 | |
| SCHEMBL780477 | 0.87 | GPR119 (0.44) | CHRNA7CHRNB2CHRNA4KCNH2DRD2 | |
| SCHEMBL779655 | 0.81 | GPR119 (0.44) | CHRNA7CHRNB2CHRNA4KCNH2DRD2 | |
| SCHEMBL780438 | 0.78 | CHRNA7 (0.47) | CHRNA7CHRNB2CHRNA4KCNH2DRD2 | |
| SCHEMBL781787 | 0.77 | CHRNA7 (0.44) | CHRNA7CHRNB2CHRNA4KCNH2 | |
| SCHEMBL780001 | 0.76 | CHRNA7 (0.71) | CHRNA7CHRNB2CHRNA4KCNH2 | |
| SCHEMBL780000 | 0.76 | CHRNA7 (0.71) | CHRNA7CHRNB2CHRNA4KCNH2 | |
| Hydrochloric Acid SCHEMBL778801 | 0.75 | CHRNA7 (0.71) | CHRNA7CHRNB2CHRNA4KCNH2 | |
| Hydrochloric Acid SCHEMBL15841836 | 0.75 | CHRNA7 (0.71) | CHRNA7CHRNB2CHRNA4KCNH2 | |
| SCHEMBL780135 | 0.73 | CHRNA7 (0.60) | CHRNA7CHRNB2CHRNA4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044038-A2 | NOVEL PIPERAZINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF | Cornerstone Therapeutics Inc. (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007146066-A2 | NOVEL PIPERAZINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF | CRITICAL THERAPEUTICS, INC. (US) | 2007-12-21 | — | — | WO | disclosed |