Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 10/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.52 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3930143 | 0.93 | PTGDR2 (0.65) | CCR5KDM4EALDH1A1PTGDR2MEN1 | |
| SCHEMBL3925686 | 0.91 | USP2 (0.51) | CCR5KDM4EALDH1A1PTGDR2PTGER1 | |
| SCHEMBL3931547 | 0.90 | CCR5 (0.62) | CCR5PTGER1MEN1KMT2A | |
| SCHEMBL3928637 | 0.89 | PTGDR2 (0.59) | CCR5KDM4EALDH1A1PTGDR2PTGER1 | |
| SCHEMBL3933437 | 0.88 | CCR5 (0.55) | CCR5 | |
| SCHEMBL3930674 | 0.88 | CCR5 (0.55) | CCR5 | |
| SCHEMBL3927295 | 0.88 | CCR5 (0.66) | CCR5KDM4EALDH1A1PTGER1RAB9A | |
| SCHEMBL3931440 | 0.88 | MEN1 (0.53) | CCR5KDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL3931507 | 0.87 | CCR5 (0.54) | CCR5 | |
| SCHEMBL3931971 | 0.87 | CCR5 (0.68) | CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044044-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007143745-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-13 | — | — | WO | disclosed |