Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.42 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.42 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3939406 | 0.87 | CHRNA7 (0.40) | CHRNA7CHRNA1CHRNB1CHRNB2CHRNB4 | |
| SCHEMBL778113 | 0.86 | POLB (0.43) | CHRNA7CHRNA1CHRNB1CHRNB2CHRNB4 | |
| SCHEMBL3939831 | 0.86 | CHRNA7 (0.41) | CHRNA7CHRNA1CHRNB1CHRNB2CHRNB4 | |
| SCHEMBL4010198 | 0.85 | CHRNA1 (0.41) | CHRNA7CHRNA1CHRNB1CHRNB2CHRNB4 | |
| SCHEMBL778202 | 0.83 | CHRNA7 (0.57) | CHRNA7 | |
| Hydrochloric Acid SCHEMBL782513 | 0.82 | KCNH2 (0.58) | — | |
| SCHEMBL3930028 | 0.79 | CHRNA1 (0.38) | CHRNA7CHRNA1CHRNB1CHRNB2CHRNB4 | |
| SCHEMBL780677 | 0.74 | GBA1 (0.42) | — | |
| SCHEMBL780080 | 0.73 | POLB (0.42) | CHRNA7CHRNA1CHRNB1CHRNB2CHRNB4 | |
| SCHEMBL779305 | 0.73 | POLB (0.42) | CHRNA7CHRNA1CHRNB1CHRNB2CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044038-A2 | NOVEL PIPERAZINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF | Cornerstone Therapeutics Inc. (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007146066-A2 | NOVEL PIPERAZINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF | CRITICAL THERAPEUTICS, INC. (US) | 2007-12-21 | — | — | WO | disclosed |