Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Dimethylformamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylformamide SCHEMBL2184966 | 0.86 | TSHR (0.53) | TSHR | |
| Dimethylformamide SCHEMBL124684 | 0.86 | TSHR (0.53) | TSHR | |
| Alcohol SCHEMBL660803 | 0.81 | TSHR (0.40) | TSHR | |
| Dimethylformamide SCHEMBL3457497 | 0.81 | — | — | |
| Dimethylformamide SCHEMBL849515 | 0.78 | — | — | |
| Alcohol SCHEMBL2204414 | 0.78 | — | — | |
| Dimethylformamide SCHEMBL4939650 | 0.77 | TSHR (0.43) | TSHR | |
| Dimethylformamide SCHEMBL9464390 | 0.77 | TSHR (0.43) | TSHR | |
| Dimethylformamide SCHEMBL1743640 | 0.76 | TSHR (0.41) | TSHR | |
| Dimethylformamide SCHEMBL3152670 | 0.76 | TSHR (0.41) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007390-A2 | 2-PYRAZ INYLBENZ IMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |