Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9105524 | 0.86 | POLB (0.75) | POLBKMT2AMAPTSMN1; SMN2HPGD | |
| SCHEMBL5284197 | 0.86 | MAPT (0.58) | POLBKMT2AMAPTTSHRNR4A1 | |
| SCHEMBL10331374 | 0.85 | POLB (0.50) | POLBKMT2AMAPTTSHRNR4A1 | |
| SCHEMBL4907149 | 0.83 | POLB (0.71) | POLBKMT2AMAPTSMN1; SMN2HPGD | |
| SCHEMBL1999759 | 0.83 | POLB (0.71) | POLBKMT2AMAPTSMN1; SMN2HPGD | |
| SCHEMBL25224506 | 0.82 | POLB (0.61) | POLBKMT2AMAPTSMN1; SMN2HPGD | |
| SCHEMBL30409231 | 0.82 | POLB (0.61) | POLBKMT2AMAPTSMN1; SMN2HPGD | |
| SCHEMBL232841 | 0.82 | POLB (0.69) | POLBKMT2AMAPTSMN1; SMN2HPGD | |
| SCHEMBL14136353 | 0.82 | SMN1; SMN2 (0.70) | POLBKMT2AMAPTSMN1; SMN2HPGD | |
| Hydrochloric Acid SCHEMBL25310714 | 0.81 | POLB (0.68) | POLBKMT2AMAPTSMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007418-A1 | NOVEL BRONCHODILATING ISOQUINOLINE AMIDES | RESPIRATORIUS AB (SE) | 2009-01-15 | — | — | WO | disclosed |