Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25224506 | 1.00 | POLB (0.61) | POLBSMN1; SMN2LMNAHTTNPSR1 | |
| SCHEMBL12491001 | 0.85 | SMN1; SMN2 (0.43) | POLBSMN1; SMN2LMNAHTTNPSR1 | |
| SCHEMBL3928781 | 0.82 | POLB (0.69) | POLBSMN1; SMN2LMNAHTTNPSR1 | |
| SCHEMBL9105524 | 0.80 | POLB (0.75) | POLBSMN1; SMN2LMNAHTTNPSR1 | |
| SCHEMBL16467131 | 0.80 | SMN1; SMN2 (0.42) | POLBSMN1; SMN2LMNAHTTNPSR1 | |
| SCHEMBL4907149 | 0.77 | POLB (0.71) | POLBSMN1; SMN2LMNAHTTNPSR1 | |
| SCHEMBL1999759 | 0.77 | POLB (0.71) | POLBSMN1; SMN2LMNAHTTNPSR1 | |
| SCHEMBL1350989 | 0.77 | POLB (0.66) | POLBSMN1; SMN2LMNAHTTNPSR1 | |
| SCHEMBL11946907 | 0.76 | ALDH1A1 (0.40) | POLBSMN1; SMN2LMNAHTTNPSR1 | |
| SCHEMBL232841 | 0.76 | POLB (0.69) | POLBSMN1; SMN2LMNAHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4436975-A1 | SPIROCYCLIC CYCLIC MODULATORS OF CHOLESTEROL BIOSYNTHESIS AND THEIR USE FOR PROMOTING REMYELINATION | Genentech, Inc. (US) | 2024-10-02 | — | — | EP | disclosed |
| CN-118696050-A | Spirocyclic cyclic modulators of cholesterol biosynthesis and their use for promoting remyelination | 基因泰克公司 | 2024-09-24 | — | — | CN | disclosed |
| WO-2023097233-A1 | SPIROCYCLIC CYCLIC MODULATORS OF CHOLESTEROL BIOSYNTHESIS AND THEIR USE FOR PROMOTING REMYELINATION | GENENTECH, INC. (US) | 2023-06-01 | — | — | WO | disclosed |