SCHEMBL392886

SCHEMBL392886

CCNS(=O)(=O)c1cccc(/C=C(\C)C(=O)O)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 2/20 0.49
HDAC1 Q13547 3/20 0.44
HDAC3 O15379 2/20 0.44
HDAC4 P56524 2/20 0.44
HDAC7 Q8WUI4 2/20 0.44
HDAC2 Q92769 2/20 0.44
HDAC10 Q969S8 2/20 0.44
HDAC11 Q96DB2 2/20 0.44
HDAC8 Q9BY41 2/20 0.44
HDAC6 Q9UBN7 2/20 0.44
HDAC9 Q9UKV0 2/20 0.44
HDAC5 Q9UQL6 2/20 0.44
ATM Q13315 1/20 0.43
ALDH1A1 P00352 5/20 0.42
LMNA P02545 3/20 0.42
TBXAS1 P24557 1/20 0.41
CYP2C19 P33261 1/20 0.41
KMT2A Q03164 2/20 0.40
BRD4 O60885 2/20 0.39
MAPT P10636 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL392887 1.00 AKR1C3 (0.49) AKR1C3HDAC1HDAC3HDAC4HDAC7
SCHEMBL397723 0.90 ATM (0.47) AKR1C3HDAC1HDAC3HDAC4HDAC7
SCHEMBL397722 0.90 ATM (0.47) AKR1C3HDAC1HDAC3HDAC4HDAC7
SCHEMBL397007 0.87 ALDH1A1 (0.49) AKR1C3HDAC1HDAC3HDAC4HDAC7
SCHEMBL397006 0.87 ALDH1A1 (0.49) AKR1C3HDAC1HDAC3HDAC4HDAC7
SCHEMBL396714 0.86 AKR1C3 (0.45) AKR1C3HDAC1HDAC3HDAC4HDAC7
SCHEMBL396715 0.86 AKR1C3 (0.45) AKR1C3HDAC1HDAC3HDAC4HDAC7
SCHEMBL398495 0.85 AKR1C3 (0.53) AKR1C3HDAC1HDAC3HDAC4HDAC7
SCHEMBL398494 0.85 AKR1C3 (0.53) AKR1C3HDAC1HDAC3HDAC4HDAC7
SCHEMBL396595 0.83 ALDH1A1 (0.52) AKR1C3HDAC1ALDH1A1LMNAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8101332-B2 Negative-working lithographic printing plate precursor and method of lithographic printing using same FUJIFILM CORPORATION (JP) 2012-01-24 US disclosed
US-20090246688-A1 NEGATIVE-WORKING LITHOGRAPHIC PRINTING PLATE PRECURSOR AND METHOD OF LITHOGRAPHIC PRINTING USING SAME FUJIFILM CORPORATION (JP) 2009-10-01 US disclosed
EP-2105298-A1 Negative-working lithographic printing plate precursor and method of lithographic printing using same Fujifilm Corporation (JP) 2009-09-30 EP disclosed