Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GPR174 | Q9BXC1 | 11/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3926150 | 0.90 | MAPT (0.41) | MAPTALDH1A1HTTSMN1; SMN2NPSR1 | |
| SCHEMBL4134812 | 0.90 | MAPT (0.38) | MAPTALDH1A1GPR174POLBSMN1; SMN2 | |
| SCHEMBL3926427 | 0.88 | MAPT (0.42) | MAPTALDH1A1GPR174HTTSMN1; SMN2 | |
| SCHEMBL4125135 | 0.88 | MAPT (0.42) | MAPTALDH1A1HTTSMN1; SMN2NPSR1 | |
| SCHEMBL13375334 | 0.81 | ABL1 (0.34) | ABL1 | |
| SCHEMBL13373566 | 0.79 | SYK (0.35) | MAPTALDH1A1POLBHTTSMN1; SMN2 | |
| SCHEMBL5952646 | 0.78 | ABL1 (0.33) | ABL1 | |
| SCHEMBL3935200 | 0.78 | CHEK2 (0.37) | MAPTALDH1A1POLBHTTLMNA | |
| SCHEMBL4124822 | 0.78 | CSF1R (0.36) | ALDH1A1ABL1 | |
| SCHEMBL3928879 | 0.78 | ATR (0.40) | ALDH1A1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041119-B1 | PYRAZOLYLBENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM AND USE THEREOF | AVENTIS PHARMA SA (FR) | 2017-05-10 | — | — | EP | disclosed |
| EP-2041119-A1 | PYRAZOLYLBENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM AND USE THEREOF | Aventis Pharma S.A. (FR) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008003857-A1 | PYRAZOLYLBENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM AND USE THEREOF | AVENTIS PHARMA S.A. (FR) | 2008-01-10 | — | — | WO | disclosed |