Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | CDC25B | P30305 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.31 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.30 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7333127 | 0.97 | TSHR (0.42) | TSHRTHRBPTPN1CDC25BHTT | |
| SCHEMBL9849421 | 0.97 | TSHR (0.42) | TSHRTHRBPTPN1CDC25BHTT | |
| SCHEMBL14058730 | 0.97 | TSHR (0.42) | TSHRTHRBPTPN1CDC25BHTT | |
| SCHEMBL10825612 | 0.86 | TSHR (0.39) | TSHRTHRBHTTLMNADNM1 | |
| SCHEMBL4396741 | 0.86 | TSHR (0.39) | TSHRTHRBHTTLMNADNM1 | |
| SCHEMBL19586815 | 0.83 | TSHR (0.37) | TSHRTHRBHTTLMNADNM1 | |
| SCHEMBL9849353 | 0.81 | TSHR (0.42) | TSHRTHRBHTTLMNADNM1 | |
| SCHEMBL9849481 | 0.79 | — | — | |
| SCHEMBL9849478 | 0.79 | TSHR (0.38) | TSHRTHRBHTTLMNA | |
| SCHEMBL11057763 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112118841-A | Spirocyclic ROR-gamma modulators | 爱思凯利尔生物科学私人有限责任公司 | 2020-12-22 | — | — | CN | claimed |
| CN-107235867-A | It is used as the aryl sultam derivative of RORc conditioning agents | 弗·哈夫曼-拉罗切有限公司 | 2017-10-10 | — | — | CN | claimed |
| CN-104470917-B | Aryl sultam derivatives as RORc modulators | 弗·哈夫曼-拉罗切有限公司 | 2017-08-04 | — | — | CN | claimed |
| CN-104470917-A | Aryl sultam derivatives as RORc modulators | HOFFMANN LA ROCHE | 2015-03-25 | — | — | CN | claimed |
| EP-0453275-A1 | Process for producing epoxy compound | NIPPON OIL CO. LTD. (JP) | 1991-10-23 | — | — | EP | claimed |
| CN-116761798-A | Indazoles as kinase inhibitors | 泰拉生物科学公司 | 2023-09-15 | — | — | CN | disclosed |
| EP-3765020-A1 | SPIROCYCLIC ROR-GAMMA MODULATORS | Escalier Biosciences B.V. (US) | 2021-01-20 | — | — | EP | disclosed |
| CN-112118841-A | Spirocyclic ROR-gamma modulators | 爱思凯利尔生物科学私人有限责任公司 | 2020-12-22 | — | — | CN | disclosed |
| WO-2019177997-A1 | SPIROCYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. (US) | 2019-09-19 | — | — | WO | disclosed |
| CN-105209448-B | Tricyclic compounds and uses thereof | 株式会社蒂奥姆生物 | 2018-09-14 | — | — | CN | disclosed |
| CN-108017603-A | Tricyclic compounds and uses thereof | 株式会社蒂奥姆生物 | 2018-05-11 | — | — | CN | disclosed |
| CN-107001281-A | Substituted benzothiophene radical derivative is used as the GPR40 activators for treating type ii diabetes | 詹森药业有限公司 | 2017-08-01 | — | — | CN | disclosed |
| EP-2041123-A2 | FUSED CYCLIC COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008001931-A2 | FUSED CYCLIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-01-03 | — | — | WO | disclosed |
| US-5554640-A | TREATMENT OF SEXUAL DYSFUNCTION, SCHEZOPHRENIA, APPATITE, GASTROINTESTINAL, AND CARDIOVASCULAR DISORDERS; ANXIOLYTIC AGENTS, ANALGESICS | ELI LILLY AND COMPANY (US) | 1996-09-10 | — | — | US | disclosed |
| US-5420294-A | 5-HT 1 antagonists, selective for serotonin receptor | ELI LILLY AND COMPANY (US) | 1995-05-30 | — | — | US | disclosed |
| EP-0345056-B1 | Improvements in and relating to serotonin antagonists | LILLY CO ELI (US) | 1995-02-01 | — | — | EP | disclosed |
| EP-0453275-A1 | Process for producing epoxy compound | NIPPON OIL CO. LTD. (JP) | 1991-10-23 | — | — | EP | disclosed |
| US-5013761-A | Selective | ELI LILLY AND COMPANY (US) | 1991-05-07 | — | — | US | disclosed |
| EP-0345056-A2 | Improvements in and relating to serotonin antagonists | ELI LILLY AND COMPANY (US) | 1989-12-06 | — | — | EP | disclosed |