Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Beclomethasone Dipropionate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 6/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.97 |
| ▸ | USP2 | O75604 | 6/20 | 0.97 |
| ▸ | PGR | P06401 | 5/20 | 0.97 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.97 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.97 |
| ▸ | AR | P10275 | 2/20 | 0.97 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.97 |
| ▸ | CNR1 | P21554 | 1/20 | 0.97 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.97 |
| ▸ | MAPT | P10636 | 3/20 | 0.78 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.78 |
| ▸ | DRD2 | P14416 | 1/20 | 0.78 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.78 |
| ▸ | LMNA | P02545 | 4/20 | 0.67 |
| ▸ | ABCB11 | O95342 | 4/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.67 |
| ▸ | MLNR | O43193 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Beclomethasone Dipropionate SCHEMBL19681908 | 0.98 | CYP3A4 (1.00) | CYP3A4USP2NR3C1PGRADORA3 | |
| Beclomethasone Dipropionate SCHEMBL10392062 | 0.98 | CYP3A4 (1.00) | CYP3A4USP2NR3C1PGRADORA3 | |
| Beclomethasone Dipropionate SCHEMBL9768491 | 0.98 | CYP3A4 (1.00) | CYP3A4USP2NR3C1PGRADORA3 | |
| Beclomethasone Dipropionate SCHEMBL6941956 | 0.98 | CYP3A4 (1.00) | CYP3A4USP2NR3C1PGRADORA3 | |
| Beclomethasone Dipropionate SCHEMBL5095 | 0.98 | CYP3A4 (1.00) | CYP3A4USP2NR3C1PGRADORA3 | |
| Beclomethasone Dipropionate SCHEMBL13653326 | 0.98 | CYP3A4 (1.00) | CYP3A4USP2NR3C1PGRADORA3 | |
| Beclomethasone Dipropionate SCHEMBL6055708 | 0.98 | CYP3A4 (1.00) | CYP3A4USP2NR3C1PGRADORA3 | |
| Beclomethasone Dipropionate SCHEMBL6055713 | 0.98 | CYP3A4 (1.00) | CYP3A4USP2NR3C1PGRADORA3 | |
| Beclomethasone Dipropionate SCHEMBL10493593 | 0.98 | CYP3A4 (1.00) | CYP3A4USP2NR3C1PGRADORA3 | |
| Beclomethasone Dipropionate SCHEMBL6890 | 0.98 | CYP3A4 (1.00) | CYP3A4USP2NR3C1PGRADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8420058-B2 | Pharmaceutical aerosol composition | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-04-16 | — | — | US | disclosed |
| US-20090311196-A1 | PHARMACEUTICAL AEROSOL COMPOSITION | CHIESI FARMACEUTICI S.P.A (IT) | 2009-12-17 | — | — | US | disclosed |
| US-7601336-B2 | Pharmaceutical aerosol composition | CHIESI FARMACEUTICI S.P.A. (IT) | 2009-10-13 | — | — | US | disclosed |
| EP-0920302-B2 | PHARMACEUTICAL AEROSOL COMPOSITION | CHIESI FARMA SPA (IT) | 2006-06-21 | — | — | EP | disclosed |
| CN-1138532-C | Medicinal Aerosol Composition | ������˹ҩƷ��˾ | 2004-02-18 | — | — | CN | disclosed |
| US-20030206870-A1 | Pharaceutical aerosol composition | CHIESI FARMACEUTICI S.P.A. (IT) | 2003-11-06 | — | — | US | disclosed |
| US-20030190287-A1 | Pharaceutical aerosol composition | CHIESI FARMACEUTICI S.P.A. (IT) | 2003-10-09 | — | — | US | disclosed |
| EP-0920302-B1 | PHARMACEUTICAL AEROSOL COMPOSITION | CHIESI FARMA SPA (IT) | 2002-08-28 | — | — | EP | disclosed |
| US-20010031244-A1 | Mixture of active materials, hydrofluoroalkane propellant and cosolvent | CHIESI FARMACEUTICI S.P.A. (IT) | 2001-10-18 | — | — | US | disclosed |
| CN-1229355-A | Medicinal Aerosol Composition | CHIESI FARMA SPA (IT) | 1999-09-22 | — | — | CN | disclosed |
| EP-0920302-A1 | PHARMACEUTICAL AEROSOL COMPOSITION | CHIESI FARMACEUTICI S.p.A. (IT) | 1999-06-09 | — | — | EP | disclosed |
| WO-1998056349-A1 | PHARMACEUTICAL AEROSOL COMPOSITION | CHIESI FARMACEUTICI S.P.A. (IT) | 1998-12-17 | — | — | WO | disclosed |