Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK2 | Q16620 | 1/20 | 0.61 |
| ▸ | RET | P07949 | 1/20 | 0.61 |
| ▸ | PRKAA1 | Q13131 | 8/20 | 0.57 |
| ▸ | KDR | P35968 | 8/20 | 0.57 |
| ▸ | PRKAA2 | P54646 | 7/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.57 |
| ▸ | FLT3 | P36888 | 4/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.57 |
| ▸ | MET | P08581 | 1/20 | 0.57 |
| ▸ | CSF1R | P07333 | 3/20 | 0.55 |
| ▸ | KIT | P10721 | 2/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | NEK2 | P51955 | 1/20 | 0.52 |
| ▸ | MELK | Q14680 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10091865 | 1.00 | NTRK2 (0.61) | NTRK2RETPRKAA1KDRPRKAA2 | |
| SCHEMBL393782 | 0.96 | NTRK2 (0.64) | NTRK2RETPRKAA1KDRPRKAA2 | |
| SCHEMBL10091883 | 0.96 | NTRK2 (0.64) | NTRK2RETPRKAA1KDRPRKAA2 | |
| SCHEMBL10091874 | 0.93 | PRKAA1 (0.66) | NTRK2RETPRKAA1KDRPRKAA2 | |
| SCHEMBL398743 | 0.93 | PRKAA1 (0.66) | NTRK2RETPRKAA1KDRPRKAA2 | |
| SCHEMBL398199 | 0.92 | KDR (0.68) | NTRK2RETPRKAA1KDRPRKAA2 | |
| SCHEMBL10091884 | 0.92 | KDR (0.68) | NTRK2RETPRKAA1KDRPRKAA2 | |
| SCHEMBL10091878 | 0.89 | CSF1R (0.63) | NTRK2RETPRKAA1KDRPRKAA2 | |
| SCHEMBL395938 | 0.89 | CSF1R (0.63) | NTRK2RETPRKAA1KDRPRKAA2 | |
| SCHEMBL4143548 | 0.89 | RET (0.67) | NTRK2RETKDRPDGFRBFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101608-B2 | 3-(4-Methyl-imidazol-1-yl)-N-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-5-trifluoromethyl-benzamide; including benign and malignant proliferative disorders as well as diseases resulting from inappropriate activation of the immune and nervous systems | IRM LLC, a Delware Limited Corporation (BM) | 2012-01-24 | — | — | US | claimed |
| US-8101608-B2 | 3-(4-Methyl-imidazol-1-yl)-N-{3-[2-oxo-3-(1H-pyrrol-2-ylmethylene)-2,3-dihydro-1H-indol-6-ylamino]-phenyl}-5-trifluoromethyl-benzamide; including benign and malignant proliferative disorders as well as diseases resulting from inappropriate activation of the immune and nervous systems | IRM LLC, a Delware Limited Corporation (BM) | 2012-01-24 | — | — | US | disclosed |