Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 2/20 | 0.67 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.62 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.61 |
| ▸ | FLT3 | P36888 | 10/20 | 0.61 |
| ▸ | KDR | P35968 | 7/20 | 0.61 |
| ▸ | FLT4 | P35916 | 4/20 | 0.61 |
| ▸ | KIT | P10721 | 3/20 | 0.60 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.58 |
| ▸ | MET | P08581 | 2/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.58 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.58 |
| ▸ | CSF1R | P07333 | 4/20 | 0.52 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4143557 | 1.00 | RET (0.67) | RETNTRK1AURKBFLT3KDR | |
| SCHEMBL4136312 | 0.95 | FLT3 (0.65) | RETNTRK1AURKBFLT3KDR | |
| SCHEMBL4000442 | 0.95 | FLT3 (0.65) | RETNTRK1AURKBFLT3KDR | |
| SCHEMBL398199 | 0.90 | KDR (0.68) | RETNTRK1AURKBFLT3KDR | |
| SCHEMBL10091884 | 0.90 | KDR (0.68) | RETNTRK1AURKBFLT3KDR | |
| SCHEMBL393047 | 0.89 | NTRK2 (0.61) | RETAURKBFLT3KDRKIT | |
| SCHEMBL10091865 | 0.89 | NTRK2 (0.61) | RETAURKBFLT3KDRKIT | |
| SCHEMBL398743 | 0.88 | PRKAA1 (0.66) | RETNTRK1AURKBFLT3KDR | |
| SCHEMBL10091874 | 0.88 | PRKAA1 (0.66) | RETNTRK1AURKBFLT3KDR | |
| SCHEMBL10091885 | 0.86 | FLT3 (0.63) | RETNTRK1AURKBFLT3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814545-A4 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-06-10 | — | — | EP | claimed |
| US-20080221192-A1 | Compounds and Compositions as Protein Kinase Inhibitors | IRM LLC (BM) | 2008-09-11 | — | — | US | claimed |
| EP-1814545-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM, LLC (BM) | 2007-08-08 | — | — | EP | claimed |
| WO-2006052936-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-05-18 | — | — | WO | claimed |
| US-20080221192-A1 | Compounds and Compositions as Protein Kinase Inhibitors | IRM LLC (BM) | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221192-A1 | Compounds and Compositions as Protein Kinase Inhibitors | BMX, FRK, PTK2B | RET 5/4885NTRK1 226/4885AURKB 164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.