Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.52 |
| ▸ | CCR5 | P51681 | 12/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3927913 | 0.91 | CCR5 (0.48) | PTGDR2CCR5KDM4EPOLB | |
| SCHEMBL3928917 | 0.88 | PTGDR2 (0.59) | PTGDR2CCR5KDM4E | |
| SCHEMBL3933946 | 0.87 | CCR5 (0.53) | PTGDR2CCR5KDM4E | |
| SCHEMBL3927925 | 0.85 | PTGDR2 (0.72) | PTGDR2CCR5KDM4E | |
| SCHEMBL3938573 | 0.84 | CCR5 (0.51) | PTGDR2CCR5 | |
| SCHEMBL3928788 | 0.84 | PTGDR2 (0.63) | PTGDR2CCR5POLB | |
| SCHEMBL3929256 | 0.84 | PTGDR2 (0.58) | PTGDR2CCR5POLB | |
| SCHEMBL3927277 | 0.83 | PTGDR2 (0.69) | PTGDR2CCR5KDM4E | |
| SCHEMBL3939464 | 0.83 | PTGDR2 (0.59) | PTGDR2CCR5 | |
| SCHEMBL3937820 | 0.82 | PTGDR2 (0.58) | PTGDR2CCR5KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044044-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007143745-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-13 | — | — | WO | disclosed |