Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 19/20 | 0.77 |
| ▸ | PLK3 | Q9H4B4 | 11/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.68 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.67 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.67 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.67 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.67 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.67 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.67 |
| ▸ | STK10 | O94804 | 1/20 | 0.67 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.67 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.67 |
| ▸ | KIT | P10721 | 1/20 | 0.67 |
| ▸ | PIM1 | P11309 | 1/20 | 0.67 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.67 |
| ▸ | GRK4 | P32298 | 1/20 | 0.67 |
| ▸ | TIE1 | P35590 | 1/20 | 0.67 |
| ▸ | FLT3 | P36888 | 1/20 | 0.67 |
| ▸ | PRKCI | P41743 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3931897 | 0.90 | PLK1 (0.63) | PLK1PLK3CYP2C9 | |
| SCHEMBL3741480 | 0.90 | PLK1 (0.74) | PLK1PLK3CYP3A4CYP2C9PIK3CD | |
| SCHEMBL3737290 | 0.90 | PLK1 (0.74) | PLK1PLK3CYP3A4CYP2C9PIK3CD | |
| SCHEMBL3737966 | 0.90 | PLK1 (0.74) | PLK1PLK3CYP3A4CYP2C9PIK3CD | |
| SCHEMBL3732503 | 0.89 | PLK1 (0.80) | PLK1PLK3CYP3A4CYP2C9 | |
| SCHEMBL4405223 | 0.88 | PLK1 (0.83) | PLK1PLK3CYP3A4CYP2C9PIK3CD | |
| SCHEMBL4035216 | 0.88 | PLK1 (0.83) | PLK1PLK3CYP3A4CYP2C9PDGFRB | |
| SCHEMBL13206495 | 0.88 | PLK1 (0.83) | PLK1PLK3CYP3A4CYP2C9PDGFRB | |
| SCHEMBL3737776 | 0.87 | PLK1 (0.70) | PLK1PLK3CYP3A4CYP2C9PIK3CD | |
| SCHEMBL3740830 | 0.87 | PLK1 (0.80) | PLK1PLK3CYP3A4CYP2C9PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009003911-A1 | THIOPHENE-IMIDAZOPYRIDINES | 4SC AG (DE) | 2009-01-08 | — | — | WO | disclosed |