Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 17/20 | 0.63 |
| ▸ | PLK3 | Q9H4B4 | 11/20 | 0.63 |
| ▸ | CDK2 | P24941 | 1/20 | 0.63 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3931682 | 0.90 | PLK1 (0.77) | PLK1PLK3CYP2C9 | |
| SCHEMBL3741864 | 0.89 | PLK1 (0.60) | PLK1PLK3CDK2IKBKECYP2C9 | |
| SCHEMBL3740997 | 0.85 | PLK1 (0.59) | PLK1PLK3CDK2IKBKECYP2C9 | |
| SCHEMBL3745101 | 0.85 | PLK1 (0.56) | PLK1PLK3CDK2IKBKECYP2C9 | |
| SCHEMBL3749457 | 0.85 | PLK1 (0.56) | PLK1PLK3CDK2IKBKECYP2C9 | |
| SCHEMBL3731446 | 0.84 | PLK1 (0.58) | PLK1PLK3CDK2IKBKECYP2C9 | |
| SCHEMBL3740675 | 0.84 | PLK1 (0.58) | PLK1PLK3CDK2IKBKECYP2C9 | |
| SCHEMBL3731989 | 0.83 | PLK1 (0.68) | PLK1PLK3CDK2IKBKECYP2C9 | |
| SCHEMBL3734763 | 0.83 | PLK1 (0.60) | PLK1PLK3CDK2IKBKECYP2C9 | |
| SCHEMBL3739968 | 0.83 | PLK1 (0.68) | PLK1PLK3CDK2IKBKECYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009003911-A1 | THIOPHENE-IMIDAZOPYRIDINES | 4SC AG (DE) | 2009-01-08 | — | — | WO | disclosed |