Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | MGAM | O43451 | 1/20 | 0.50 |
| ▸ | SI | P14410 | 1/20 | 0.50 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10012033 | 0.83 | GAA (0.52) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL1227376 | 0.79 | GAA (0.43) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL3080890 | 0.78 | — | — | |
| SCHEMBL15164100 | 0.77 | GAA (0.46) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL15164019 | 0.77 | GAA (0.46) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL15164020 | 0.77 | GAA (0.46) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL15956041 | 0.77 | TDP1 (0.33) | ALOX15 | |
| SCHEMBL6220404 | 0.74 | GAA (0.43) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL2682415 | 0.74 | GAA (0.60) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL9694127 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 140 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3309159-B1 | CRYSTAL OF 5-HYDROXY-4-(TRIFLUOROMETHYL)PYRAZOLOPYRIDINE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2020-11-25 | — | — | EP | disclosed |
| US-10138240-B2 | Crystal of 5-hydroxy-4-(trifluoromethyl)pyrazolopyridine derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2018-11-27 | — | — | US | disclosed |
| US-20180170926-A1 | CRYSTAL OF 5-HYDROXY-4-(TRIFLUOROMETHYL)PYRAZOLOPYRIDINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2018-06-21 | — | — | US | disclosed |
| EP-3309159-A1 | CRYSTAL OF 5-HYDROXY-4-(TRIFLUOROMETHYL)PYRAZOLOPYRIDINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2018-04-18 | — | — | EP | disclosed |
| EP-3081566-B1 | 5-HYDROXY-4-(TRIFLUOROMETHYL)PYRAZOLOPYRIDINE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2018-03-07 | — | — | EP | disclosed |
| US-9796709-B2 | 5-hydroxy-4-(trifluoromethyl)pyrazolopyridine derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2017-10-24 | — | — | US | disclosed |
| US-20160376267-A1 | 5-HYDROXY-4-(TRIFLUOROMETHYL)PYRAZOLOPYRIDINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2016-12-29 | — | — | US | disclosed |
| EP-3081566-A1 | 5-HYDROXY-4-(TRIFLUOROMETHYL)PYRAZOLOPYRIDINE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2016-10-19 | — | — | EP | disclosed |
| US-7541458-B2 | β-lactam synthesis | FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2009-06-02 | — | — | US | disclosed |
| EP-1888522-A2 | ß-LACTAM SYNTHESIS | Florida State University Research Foundation, Inc. (US) | 2008-02-20 | — | — | EP | disclosed |
| WO-1994017050-A1 | C7 TAXANE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FLORIDA STATE UNIVERSITY (US) | 1994-08-04 | — | — | WO | disclosed |
| WO-1994015599-A1 | C10 TAXANE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS | FLORIDA STATE UNIVERSITY (US) | 1994-07-21 | — | — | WO | disclosed |
| EP-0605637-A1 | PREPARATION OF SUBSTITUTED ISOSERINE ESTERS USING METAL ALKOXIDES AND $g(b)-LACTAMS | FLORIDA STATE UNIVERSITY (US) | 1994-07-13 | — | — | EP | disclosed |
| EP-0605638-A1 | METAL ALKOXIDES | FLORIDA STATE UNIVERSITY (US) | 1994-07-13 | — | — | EP | disclosed |
| WO-1994010996-A1 | BUTENYL-SUBSTITUTED TAXANES AND COMPOSITION | FLORIDA STATE UNIVERSITY (US) | 1994-05-26 | — | — | WO | disclosed |
| WO-1994010997-A1 | TAXANES HAVING AN ALKYL SUBSTITUTED SIDE-CHAIN AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FLORIDA STATE UNIVERSITY (US) | 1994-05-26 | — | — | WO | disclosed |
| US-5274124-A | Metal alkoxides | FLORIDA STATE UNIVERSITY (US) | 1993-12-28 | — | — | US | disclosed |
| US-5229526-A | METAL ALKOXIDES | FLORIDA STATE UNIVERSITY (US) | 1993-07-20 | — | — | US | disclosed |
| WO-1993006079-A1 | PREPARATION OF SUBSTITUTED ISOSERINE ESTERS USING METAL ALKOXIDES AND β-LACTAMS | FLORIDA STATE UNIVERSITY (US) | 1993-04-01 | — | — | WO | disclosed |
| WO-1993006094-A1 | METAL ALKOXIDES | FLORIDA STATE UNIVERSITY (US) | 1993-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160376267-A1 | 5-HYDROXY-4-(TRIFLUOROMETHYL)PYRAZOLOPYRIDINE DERIVATIVE | LDLR, LCAT, LPL | GAA 517/4885MGAM 2696/4885SI 1676/4885 |
| US-20180170926-A1 | CRYSTAL OF 5-HYDROXY-4-(TRIFLUOROMETHYL)PYRAZOLOPYRIDINE DERIVATIVE | LDLR, LCAT, LPL | GAA 1036/4885MGAM 3042/4885SI 2042/4885 |
| US-10138240-B2 | Crystal of 5-hydroxy-4-(trifluoromethyl)pyrazolopyridine derivative | LDLR, LCAT, LPL | GAA 1036/4885MGAM 3042/4885SI 2042/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.