SCHEMBL3932070

SCHEMBL3932070

Cc1ccc(S(=O)(=O)N2CCCC(c3cccc(CC(=O)O)c3)C2)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.50
BCL9 O00512 3/20 0.49
CTNNB1 P35222 3/20 0.49
GAA P10253 2/20 0.48
POLB P06746 2/20 0.48
KMT2A Q03164 2/20 0.48
LMNA P02545 1/20 0.48
TSHR P16473 1/20 0.48
HTT P42858 1/20 0.48
MEN1 O00255 1/20 0.48
USP5 P45974 2/20 0.48
PTGDR2 Q9Y5Y4 1/20 0.48
PKM P14618 1/20 0.47
DRD2 P14416 1/20 0.46
DRD1 P21728 1/20 0.46
DRD4 P21917 1/20 0.46
DRD5 P21918 1/20 0.46
DRD3 P35462 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
USP2 O75604 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3930676 0.92 BCL9 (0.49) BCL9CTNNB1KMT2AMEN1USP5
SCHEMBL3941700 0.92 BCL9 (0.54) ALDH1A1BCL9CTNNB1GAAKMT2A
SCHEMBL3939581 0.91 BCL9 (0.52) ALDH1A1BCL9CTNNB1GAAUSP5
SCHEMBL3937652 0.91 MEN1 (0.50) ALDH1A1BCL9CTNNB1KMT2ALMNA
SCHEMBL3941517 0.90 MAPT (0.55) ALDH1A1BCL9CTNNB1GAAPOLB
SCHEMBL4110985 0.90 SMN1; SMN2 (0.48) BCL9CTNNB1GAAPOLBKMT2A
SCHEMBL3938045 0.90 MAPT (0.55) ALDH1A1BCL9CTNNB1GAAPOLB
SCHEMBL14366755 0.90 MEN1 (0.48) BCL9CTNNB1KMT2AMEN1USP5
SCHEMBL3929084 0.90 MAPT (0.55) ALDH1A1BCL9CTNNB1GAAPOLB
SCHEMBL3940596 0.89 MEN1 (0.53) ALDH1A1BCL9CTNNB1GAAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2044017-A2 SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS ICOS CORPORATION (US) 2009-04-08 EP claimed
WO-2007146838-A2 SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS ICOS CORPORATION (US) 2007-12-21 WO claimed
EP-2044017-A2 SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS ICOS CORPORATION (US) 2009-04-08 EP disclosed
WO-2007146838-A2 SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS ICOS CORPORATION (US) 2007-12-21 WO disclosed
WO-2007146838-A2 SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS ICOS CORPORATION (US) 2007-12-21 WO disclosed