Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | BCL9 | O00512 | 7/20 | 0.48 |
| ▸ | CTNNB1 | P35222 | 7/20 | 0.48 |
| ▸ | USP5 | P45974 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3932070 | 0.91 | ALDH1A1 (0.50) | MEN1KMT2AALDH1A1BCL9CTNNB1 | |
| SCHEMBL3930676 | 0.91 | BCL9 (0.49) | MEN1KMT2ABCL9CTNNB1USP5 | |
| SCHEMBL3941700 | 0.91 | BCL9 (0.54) | MEN1KMT2AALDH1A1BCL9CTNNB1 | |
| SCHEMBL3936472 | 0.89 | TP53 (0.48) | MEN1KMT2AALDH1A1TP53BCL9 | |
| SCHEMBL3938045 | 0.89 | MAPT (0.55) | MEN1KMT2AALDH1A1TP53BCL9 | |
| SCHEMBL14366755 | 0.89 | MEN1 (0.48) | MEN1KMT2ABCL9CTNNB1USP5 | |
| SCHEMBL3941517 | 0.89 | MAPT (0.55) | MEN1KMT2AALDH1A1TP53BCL9 | |
| SCHEMBL3929084 | 0.89 | MAPT (0.55) | MEN1KMT2AALDH1A1TP53BCL9 | |
| SCHEMBL4110985 | 0.89 | SMN1; SMN2 (0.48) | MEN1KMT2ABCL9CTNNB1USP5 | |
| SCHEMBL3932074 | 0.88 | BCL9 (0.58) | MEN1KMT2AALDH1A1BCL9CTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044017-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | claimed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | claimed |
| EP-2044017-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |