Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.56 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.52 |
| ▸ | CDK4 | P11802 | 3/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.31 |
| ▸ | CCND1 | P24385 | 3/20 | 0.31 |
| ▸ | CDK2 | P24941 | 3/20 | 0.31 |
| ▸ | CCND3 | P30281 | 3/20 | 0.31 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.31 |
| ▸ | CDK1 | P06493 | 2/20 | 0.31 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.31 |
| ▸ | CDK7 | P50613 | 2/20 | 0.31 |
| ▸ | CDK9 | P50750 | 2/20 | 0.31 |
| ▸ | CCNH | P51946 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3921424 | 0.91 | CRHR1 (0.56) | CRHR1CRHR2 | |
| SCHEMBL3925880 | 0.89 | CRHR1 (0.58) | CRHR1CRHR2CCNA2CDK2CCNT1 | |
| SCHEMBL3926385 | 0.88 | CRHR1 (0.57) | CRHR1CRHR2 | |
| SCHEMBL13614548 | 0.88 | CRHR1 (0.57) | CRHR1CRHR2CDK4CDK2CDK1 | |
| SCHEMBL3932532 | 0.87 | CRHR1 (0.54) | CRHR1CRHR2 | |
| SCHEMBL3926829 | 0.86 | CRHR1 (0.55) | CRHR1CRHR2MAPK14 | |
| SCHEMBL3931252 | 0.86 | CRHR1 (0.51) | CRHR1CRHR2 | |
| SCHEMBL3931255 | 0.85 | CRHR1 (0.50) | CRHR1CRHR2 | |
| SCHEMBL3923292 | 0.84 | CRHR1 (0.49) | CRHR1CRHR2 | |
| SCHEMBL3935105 | 0.84 | CRHR1 (0.53) | CRHR1CRHR2CDK4CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869049-B1 | IMIDAZOPYRIDAZINE COMPOUNDS | LILLY CO ELI (US) | 2009-03-04 | — | — | EP | disclosed |