Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | STAT3 | P40763 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3931978 | 0.97 | MEN1 (0.54) | PTGDR2TP53MEN1KMT2AALDH1A1 | |
| SCHEMBL3929213 | 0.93 | MEN1 (0.50) | PTGDR2TP53MEN1KMT2AALDH1A1 | |
| SCHEMBL3928769 | 0.93 | PTGDR2 (0.61) | PTGDR2TP53MEN1KMT2AALDH1A1 | |
| SCHEMBL3937820 | 0.93 | PTGDR2 (0.58) | PTGDR2TP53MEN1KMT2AALDH1A1 | |
| SCHEMBL3928218 | 0.92 | ALDH1A1 (0.51) | PTGDR2TP53MEN1KMT2AALDH1A1 | |
| SCHEMBL3928709 | 0.92 | TP53 (0.55) | PTGDR2TP53MEN1KMT2AALDH1A1 | |
| SCHEMBL3928708 | 0.91 | PTGDR2 (0.54) | PTGDR2TP53ALDH1A1KDM4EPKM | |
| SCHEMBL3931983 | 0.90 | MEN1 (0.48) | PTGDR2TP53MEN1KMT2AALDH1A1 | |
| SCHEMBL3932032 | 0.90 | ALDH1A1 (0.49) | PTGDR2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL3936773 | 0.90 | PTGDR2 (0.60) | PTGDR2MEN1KMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044044-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | claimed |
| WO-2007143745-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-13 | — | — | WO | claimed |
| EP-2044044-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007143745-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-13 | — | — | WO | disclosed |