Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.60 |
| ▸ | PPARG | P37231 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.51 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 2/20 | 0.51 |
| ▸ | RAF1 | P04049 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3938171 | 0.97 | PPARG (0.61) | MAPK14PPARGRAB9AMAPTCYP1A2 | |
| SCHEMBL3938272 | 0.88 | PPARG (0.59) | MAPK14PPARGRAB9AMAPTCYP1A2 | |
| SCHEMBL5897072 | 0.83 | MAPK14 (0.64) | MAPK14PPARGBRAFRAF1MAPK13 | |
| SCHEMBL6249153 | 0.81 | PPARG (0.52) | MAPK14PPARGRAB9ALMNAL3MBTL1 | |
| SCHEMBL6253060 | 0.81 | MAPK13 (0.61) | MAPK14PPARGRAB9AMAPTLMNA | |
| SCHEMBL6254089 | 0.80 | MAPK13 (0.61) | MAPK14PPARGMAPTLMNASMN1; SMN2 | |
| SCHEMBL3933324 | 0.79 | PPARG (0.52) | MAPK14PPARGRAB9AMAPTCYP1A2 | |
| SCHEMBL3929810 | 0.78 | MAPK14 (0.53) | MAPK14PPARGRAB9AMAPTCYP1A2 | |
| SCHEMBL5896834 | 0.77 | MAPK14 (0.66) | MAPK14PPARGMAPTLMNAHTT | |
| SCHEMBL27699896 | 0.77 | SMN1; SMN2 (0.66) | MAPK14PPARGRAB9AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | claimed |
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| WO-2006067445-A2 | CSF-1R KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | WO | disclosed |